Characteristics of lung cancer after a previous malignancy

• Verfasst von: Reinmuth, Niels [VerfasserIn]
• Verfasst von: Stumpf, Patrick [VerfasserIn]
• Verfasst von: Stumpf, Andreas [VerfasserIn]
• Verfasst von: Muley, Thomas [VerfasserIn]
• Verfasst von: Kobinger, Sonja [VerfasserIn]
• Verfasst von: Hoffmann, Hans [VerfasserIn]
• Verfasst von: Herth, Felix [VerfasserIn]
• Verfasst von: Schnabel, Philipp Albert [VerfasserIn]
• Verfasst von: Bischoff, Helge [VerfasserIn]
• Verfasst von: Thomas, Michael [VerfasserIn]
• Titel: Characteristics of lung cancer after a previous malignancy
• Verf.angabe: Niels Reinmuth, Patrick Stumpf, Andreas Stumpf, Thomas Muley, Sonja Kobinger, Hans Hoffmann, Felix J. F. Herth, Philipp A. Schnabel, Helge Bischoff, Michael Thomas
• E-Jahr: 2014
• Jahr: 5 March 2014
• Umfang: 8 S.
• Fussnoten: Gesehen am 14.08.2020
• Titel Quelle: Enthalten in: Respiratory medicine
• Ort Quelle: Burlington, Mass. : Harcourt, 1999
• Jahr Quelle: 2014
• Band/Heft Quelle: 108(2014), 6, Seite 910-917
• ISSN Quelle: 1532-3064
• DOI: doi:10.1016/j.rmed.2014.02.015
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Follow-up
• Sach-SW: Non-small cell lung cancer
• Sach-SW: Previous malignancy
• Sach-SW: Second malignancy
• Sach-SW: Survival
• K10plus-PPN: 1727088514

Abstract

Background - In the era of improving overall survival rates of malignant diseases, the impact of a previous malignancy (PM) on treatment and outcome of lung cancer (LC) remains unclear. - Methods - We reviewed all LC patients from our institution that were treated from 2004 to 2006 for the occurrence of LC with PM excluding patients with multiple primary LC. - Results - A total of 444 and 2698 LC patients with and without a history of a PM were identified (prevalence of 14.1%). PM were most often located in breast (15.5%), prostate (14.9%), bladder (9.0%) and kidney (8.8%). Compared to never smokers, patients with nicotine consumption had more often a cancer history of prostate, gastrointestinal, and the head-neck region. The median interval until diagnosis of LC was 72.2 months (range 0-537 months) with most LC diagnosed 5 years after PM diagnosis. With a similar distribution of histology, stage and localization compared to controls, NSCLC patients with PM and stage IV disease showed a favorable overall survival (p < 0.0001). In contrast, SCLC patients had similar survival curves (n.s.). - Conclusions - A considerable subgroup of LC patients has a history of PM that may indicate a favorable prognostic factor. However, these patients should be treated similar to other LC patients.