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Verfasst von:Eggert-Kruse, Waltraud [VerfasserIn]   i
 Scholz, Sandra [VerfasserIn]   i
 Kirschfink, Michael [VerfasserIn]   i
 Strowitzki, Thomas [VerfasserIn]   i
Titel:Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein
Titelzusatz:is there an association?
Verf.angabe:Waltraud Eggert-Kruse, MD, Sandra Scholz, MD, Michael Kirschfink, PhD, and Thomas Strowitzki, MD
E-Jahr:2014
Jahr:March 26, 2014
Umfang:6 S.
Fussnoten:Gesehen am 17.08.2020
Titel Quelle:Enthalten in: Fertility and sterility
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1950
Jahr Quelle:2014
Band/Heft Quelle:101(2014), 6, Seite 1675-1680
ISSN Quelle:1556-5653
Abstract:Objective - To evaluate a potential association of immunity to the Chlamydia trachomatis 60kDa heat shock protein (ChlamHSP60) and recurrent miscarriages. - Design - Prospective study. - Setting - Outpatient miscarriage clinic of a university-based hospital. - Patient(s) - 120 asymptomatic women with a history of recurrent miscarriages. - Intervention(s) - None. - Main Outcome Measure(s) - Determination of serum immunoglobulin G (IgG) antibodies (Ab) to ChlamHSP60 and human HSP60 and, in parallel, mannose-binding lectin (MBL) and the total hemolytic complement (CH50); medical history and clinical examination, including multiple relevant laboratory determinants. - Result(s) - ChlamHSP60 Ab were detected in 24 (20%) of 120 patients. Antibodies to human HSP60 were found in 19 (15.8%) of 120 patients, and more frequently in individuals who tested positive for ChlamHSP60. ChlamHSP60 were statistically significantly associated with antichlamydial IgG Ab. However, antibodies to ChlamHSP60 were not related to medical history, the number of abortions, or the time frame of fetal loss. ChlamHSP60 antibodies were not associated with the relevant variables of the coagulation cascade, a panel of autoimmune parameters including thyroid autoimmunity, deficiencies of the complement system (low MBL), or with antibodies to common infectious diseases. No statistically significant differences were was found when comparing the prevalence of ChlamHSP60 Ab in the study group with recurrent miscarriages and 90 controls (women attending for an annual pelvic examination). - Conclusion(s) - Immunity to ChlamHSP60 does not play a major role in the etiology of recurrent miscarriages.
DOI:doi:10.1016/j.fertnstert.2014.02.048
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.fertnstert.2014.02.048
 Volltext: http://www.sciencedirect.com/science/article/pii/S0015028214002015
 DOI: https://doi.org/10.1016/j.fertnstert.2014.02.048
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chlamydial 60kDa heat shock protein (Chlam HSP60)
 complement
 heat shock proteins (HSP)
 mannose-binding lectin (MBL)
 recurrent miscarriages
 sexually transmitted diseases (STD)
 subclinical infection/inflammation markers
K10plus-PPN:1727142322
Verknüpfungen:→ Zeitschrift

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