Status: Bibliographieeintrag
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| Verfasst von: | McKee, Dwight L. [VerfasserIn]  |
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| | Sternberg, Ariane [VerfasserIn] |
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| | Stange, Ulrike [VerfasserIn] |
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| | Laufer, Stefan [VerfasserIn] |
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| | Naujokat, Cord [VerfasserIn] |
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| Titel: | Candidate drugs against SARS-CoV-2 and COVID-19 |
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| Verf.angabe: | Dwight L. McKee, Ariane Sternberg, Ulrike Stange, Stefan Laufer, Cord Naujokat |
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| E-Jahr: | 2020 |
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| Jahr: | 29 April 2020 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 17.08.2020 |
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| Titel Quelle: | Enthalten in: Pharmacological research |
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| Ort Quelle: | London : Academic Press, 1969 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 157(2020) Artikel-Nummer 104859, 9 Seiten |
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| ISSN Quelle: | 1096-1186 |
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| Abstract: | Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2. Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of angiotensin-converting enzyme 2 (ACE2). Blockade of ACE2, the host cell receptor for the S protein of SARS-CoV-2 and inhibition of TMPRSS2, which is required for S protein priming may prevent cell entry of SARS-CoV-2. Further, chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may limit spread of SARS-CoV-2 and morbidity and mortality of COVID-19 pandemic. |
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| DOI: | doi:10.1016/j.phrs.2020.104859 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.phrs.2020.104859 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1043661820311671 |
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| | DOI: https://doi.org/10.1016/j.phrs.2020.104859 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Arbidol |
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| | Camostat |
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| | Chloroquine |
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| | COVID-19 |
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| | Drugs |
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| | Favipiravir |
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| | Lopinavir |
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| | Phytochemicals |
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| | Remdesivir |
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| | Ritonavir |
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| | SARS-CoV-2 |
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| K10plus-PPN: | 1727146026 |
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| Verknüpfungen: | → Zeitschrift |
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Candidate drugs against SARS-CoV-2 and COVID-19 / McKee, Dwight L. [VerfasserIn]; 29 April 2020 (Online-Ressource)
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