| |  Online-Ressource |
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| Verfasst von: | Helmstetter, Caroline [VerfasserIn]  |
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| | Flossdorf, Michael [VerfasserIn] |
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| | Peine, Michael [VerfasserIn] |
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| | Kupz, Andreas [VerfasserIn] |
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| | Zhu, Jinfang [VerfasserIn] |
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| | Hegazy, Ahmed N. [VerfasserIn] |
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| | Duque-Correa, Maria A. [VerfasserIn] |
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| | Zhang, Qin [VerfasserIn] |
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| | Vainshtein, Yevhen [VerfasserIn] |
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| | Radbruch, Andreas [VerfasserIn] |
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| | Kaufmann, Stefan H. [VerfasserIn] |
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| | Paul, William E. [VerfasserIn] |
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| | Höfer, Thomas [VerfasserIn] |
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| | Löhning, Max [VerfasserIn] |
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| Titel: | Individual T helper cells have a quantitative cytokine memory |
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| Verf.angabe: | Caroline Helmstetter, Michael Flossdorf, Michael Peine, Andreas Kupz, Jinfang Zhu, Ahmed N. Hegazy, Maria A. Duque-Correa, Qin Zhang, Yevhen Vainshtein, Andreas Radbruch, Stefan H. Kaufmann, William E. Paul, Thomas Höfer, Max Löhning |
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| Jahr: | 2015 |
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| Umfang: | 15 S. |
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| Fussnoten: | Available online 25 December 2014 ; Gesehen am 17.08.2020 |
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| Titel Quelle: | Enthalten in: Immunity |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1994 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 42(2015), 1, Seite 108-122 |
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| ISSN Quelle: | 1097-4180 |
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| Abstract: | The probabilistic expression of cytokine genes in differentiated T helper (Th) cell populations remains ill defined. By single-cell analyses and mathematical modeling, we show that one stimulation featured stable cytokine nonproducers as well as stable producers with wide cell-to-cell variability in the magnitude of expression. Focusing on interferon-γ (IFN-γ) expression by Th1 cells, mathematical modeling predicted that this behavior reflected different cell-intrinsic capacities and not mere gene-expression noise. In vivo, Th1 cells sort purified by secreted IFN-γ amounts preserved a quantitative memory for both probability and magnitude of IFN-γ re-expression for at least 1 month. Mechanistically, this memory resulted from quantitatively distinct transcription of individual alleles and was controlled by stable expression differences of the Th1 cell lineage-specifying transcription factor T-bet. Functionally, Th1 cells with graded IFN-γ production competence differentially activated Salmonella-infected macrophages for bacterial killing. Thus, individual Th cells commit to produce distinct amounts of a given cytokine, thereby generating functional intrapopulation heterogeneity. |
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| DOI: | doi:10.1016/j.immuni.2014.12.018 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.immuni.2014.12.018 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1074761314004853 |
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| | DOI: https://doi.org/10.1016/j.immuni.2014.12.018 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1727149858 |
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| Verknüpfungen: | → Zeitschrift |
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Individual T helper cells have a quantitative cytokine memory / Helmstetter, Caroline [VerfasserIn]; 2015 (Online-Ressource)
