| |  Online-Ressource |
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| Verfasst von: | Neuman, Manuela G. [VerfasserIn]  |
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| | Seitz, Helmut K. [VerfasserIn] |
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| | Mueller, Sebastian [VerfasserIn] |
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| Titel: | Alcoholic liver disease |
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| Titelzusatz: | clinical and translational research |
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| Verf.angabe: | Manuela G. Neuman, Stephen Malnick, Yaakov Maor, Radu M. Nanau, Ehud Melzer, Peter Ferenci, Helmut K. Seitz, Sebastian Mueller, Haim Mell, Didier Samuel, Lawrence B. Cohen, Kusum K. Kharbanda, Natalia A. Osna, Murali Ganesan, Kyle J. Thompson, Iain H. McKillop, Abraham Bautista, Ramon Bataller, Samuel W. French |
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| E-Jahr: | 2015 |
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| Jahr: | 3 September 2015 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 17.08.2020 |
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| Titel Quelle: | Enthalten in: Experimental and molecular pathology |
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| Ort Quelle: | Orlando, Fla. : Academic Press, 1962 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 99(2015), 3, Seite 596-610 |
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| ISSN Quelle: | 1096-0945 |
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| Abstract: | The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical research, translational research, pathogenesis and therapies. A special accent is placed on alcohol misuse, as alcohol is a legally commercialized and taxable product. Drinking alcohol, particularly from a young age, is a major health problem. Alcoholism is known to contribute to morbidity and mortality. A systematic literature search was performed in order to obtain updated data (2008-2015). The review is focused on genetic polymorphisms of alcohol metabolizing enzymes and the role of cytochrome p450 2E1 and iron in ALD. Alcohol-mediated hepatocarcinogenesis is also discussed in the presence or absence of co-morbidities such as viral hepatitis C as well as therapeutic the role of innate immunity in ALD-HCV. Moreover, emphasis was placed on alcohol and drug interactions, as well as liver transplantation for end-stage ALD. Finally, the time came to eradicate alcohol-induced liver and intestinal damage by using betaine. |
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| DOI: | doi:10.1016/j.yexmp.2015.09.001 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.yexmp.2015.09.001 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0014480015001859 |
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| | DOI: https://doi.org/10.1016/j.yexmp.2015.09.001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alcoholic liver disease |
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| | Alcohol dehydrogenase |
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| | Betaine |
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| | CYP2E1 |
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| | Hepatitis B and C viral infection |
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| | Hepatocarcinogenesis |
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| | Human immunodeficiency virus |
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| | Liver fibrosis |
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| | Liver transplant |
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| K10plus-PPN: | 1727170431 |
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| Verknüpfungen: | → Zeitschrift |
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Alcoholic liver disease / Neuman, Manuela G. [VerfasserIn]; 3 September 2015 (Online-Ressource)
