Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Liew, Hans [VerfasserIn]  |
|---|
| | Mein, Stewart [VerfasserIn] |
|---|
| | Debus, Jürgen [VerfasserIn] |
|---|
| | Dokić, Ivana [VerfasserIn] |
|---|
| | Mairani, Andrea [VerfasserIn] |
|---|
| Titel: | Modeling direct and indirect action on cell survival after photon irradiation under normoxia and hypoxia |
|---|
| Verf.angabe: | Hans Liew, Stewart Mein, Jürgen Debus, Ivana Dokic and Andrea Mairani |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 14 May 2020 |
|---|
| Umfang: | 10 S. |
|---|
| Fussnoten: | Gesehen am 19.08.2020 |
|---|
| Titel Quelle: | Enthalten in: International journal of molecular sciences |
|---|
| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 21(2020,10) Artikel-Nummer 3471, 10 Seiten |
|---|
| ISSN Quelle: | 1422-0067 |
|---|
| | 1661-6596 |
|---|
| Abstract: | The demand for personalized medicine in radiotherapy has been met by a surge of mechanistic models offering predictions of the biological effect of ionizing radiation under consideration of a growing number of parameters. We present an extension of our existing model of cell survival after photon irradiation to explicitly differentiate between the damage inflicted by the direct and indirect (radicals-mediated) action of ionizing radiation. Within our approach, we assume that the oxygenation status affects the indirect action. The effect of different concentrations of dimethyl sulfoxide (DMSO), an effective radical scavenger, has been simulated at different dose levels in normoxic and hypoxic conditions for various cell lines. Our model is found to accurately predict experimental data available in literature, validating the assumptions made in our approach. The presented extension adds further flexibility to our model and could act as basis for further developments of our model. |
|---|
| DOI: | doi:10.3390/ijms21103471 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms21103471 |
|---|
| | DOI: https://doi.org/10.3390/ijms21103471 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | direct and indirect damage |
|---|
| | dmso |
|---|
| | dna |
|---|
| | double-strand breaks |
|---|
| | hypoxia |
|---|
| | induction |
|---|
| | ionizing radiation |
|---|
| | ionizing-radiation |
|---|
| | mammalian-cells |
|---|
| | modeling |
|---|
| | oxygen |
|---|
| | protection |
|---|
| | radical scavengers |
|---|
| | radicals |
|---|
| | radioprotection |
|---|
| | x-rays |
|---|
| K10plus-PPN: | 1727418069 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Modeling direct and indirect action on cell survival after photon irradiation under normoxia and hypoxia / Liew, Hans [VerfasserIn]; 14 May 2020 (Online-Ressource)
68628653
