Indirect evidence for proton pump inhibitor failure in patients taking them independent of meals

• Verfasst von: Freigofas, Julia [VerfasserIn]
• Verfasst von: Haefeli, Walter E. [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Quinzler, Renate [VerfasserIn]
• Titel: Indirect evidence for proton pump inhibitor failure in patients taking them independent of meals
• Verf.angabe: Julia Freigofas, Walter E. Haefeli, Ben Schöttker, Hermann Brenner, Renate Quinzler
• E-Jahr: 2014
• Jahr: 10 April 2014
• Umfang: 5 S.
• Teil: volume:23
• Teil: year:2014
• Teil: number:7
• Teil: pages:768-772
• Teil: extent:5
• Fussnoten: Gesehen am 20.08.2020
• Titel Quelle: Enthalten in: Pharmacoepidemiology and drug safety
• Ort Quelle: Chichester [u.a.] : Wiley, 1992
• Jahr Quelle: 2014
• Band/Heft Quelle: 23(2014), 7, Seite 768-772
• ISSN Quelle: 1099-1557
• DOI: doi:10.1002/pds.3620
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Indirect evidence for proton pump inhibitor failure in patients taking them independent of meals. - 2014
• Sach-SW: food intake
• Sach-SW: pharmacoepidemiology
• Sach-SW: proton pump inhibitor
• Sach-SW: treatment failure
• K10plus-PPN: 1727534077

Abstract

Purpose: We investigated the association between conditions of proton pump inhibitor (PPI) treatment failure and food intake in an elderly ambulatory population. Methods: Our data originate from a large population-based cohort study. During a home visit done by a trained study physician, patients were asked for each medication to state whether it was taken in relation to a meal (before, concurrently with, and after) or independent of a meal. This information was analyzed for all patients taking a PPI daily and correlated to markers of PPI failure. Results: Out of 2717 patients participating in a home visit and taking at least one medication, 383 took a PPI daily (14.1%). A PPI intake independent of meals was defined as incorrect and was observed in 64 patients, whereas 319 patients took their PPI in relation to a meal, which was defined as the correct intake. Treatment failure was observed in 10 out of 64 (15.6%) PPI users with incorrect intake and in 18 out of 319 (5.6%) PPI users with correct intake. The risk of treatment failure was threefold higher in patients taking their PPI independent of meals (OR 3.35; 95%CI 1.44-7.76). Conclusion: The higher risk for PPI failure in patients taking PPIs independent of meals suggests that synchronized PPI administration with meals is indeed essential, and better counseling of patients is needed.