ATG induction in renal transplant recipients

• Verfasst von: Weimer, Rolf [VerfasserIn]
• Verfasst von: Ettrich, Maryam [VerfasserIn]
• Verfasst von: Renner, Fabrice [VerfasserIn]
• Verfasst von: Dietrich, Hartmut [VerfasserIn]
• Verfasst von: Süsal, Caner [VerfasserIn]
• Verfasst von: Deisz, Sabine [VerfasserIn]
• Verfasst von: Padberg, Winfried [VerfasserIn]
• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Titel: ATG induction in renal transplant recipients
• Titelzusatz: long-term hazard of severe infection is associated with long-term functional T cell impairment but not the ATG-induced CD4 cell decline
• Verf.angabe: Rolf Weimer, Maryam Ettrich, Fabrice Renner, Hartmut Dietrich, Caner Süsal, Sabine Deisz, Winfried Padberg, Gerhard Opelz
• E-Jahr: 2014
• Jahr: 12 February 2014
• Umfang: 9 S.
• Fussnoten: Gesehen am 20.08.2020
• Titel Quelle: Enthalten in: Human immunology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1980
• Jahr Quelle: 2014
• Band/Heft Quelle: 75(2014), 6, Seite 561-569
• ISSN Quelle: 1879-1166
• DOI: doi:10.1016/j.humimm.2014.02.015
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1727541510

Abstract

Background and methods - We showed previously that rabbit ATG induction induces a strong decrease of CD4+ T cells together with impaired in vitro IL-2 secretion up to 1year post-transplant. To further characterize long-term immunological effects of ATG induction 2 and 5years post-transplant, we used sensitive intracellular cytokine analysis in the same prospective study of 84 renal transplant recipients (ATG, n=44). - Results - A significantly increased frequency of severe infectious disease (HR=2.0, p=0.027) as well as suppressed T cell functions were found within 2years after ATG induction but not beyond (logistic regression (logreg): CD4 cell IL-10 responses, p=0.064; T cell proliferation, p=0.038). Impaired T cell proliferation at 2years was associated with occurrence of severe infection (p=0.017). Importantly, a strong and persistent decrease of CD4 cell counts (p<0.0005 at 5years) was independently associated with ATG induction (logreg p=0.002) but not related to functional CD4 cell impairment (helper activity/cytokine production) or an increased risk of infection. - Conclusions - Severe infection up to 2years after ATG induction was associated with impaired T cell proliferative capacity but not with the profound decline in CD4 cell counts that occurred after ATG induction and persisted up to 5years.