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Verfasst von:Raftery, Martin J. [VerfasserIn]   i
 Lalwani, Pritesh Jaychand [VerfasserIn]   i
 Lütteke, Nina [VerfasserIn]   i
 Kobak, Lidija [VerfasserIn]   i
 Giese, Thomas [VerfasserIn]   i
 Ulrich, Rainer [VerfasserIn]   i
 Radosa, Lukáš [VerfasserIn]   i
 Krüger, Detlev H. [VerfasserIn]   i
 Schönrich, Günther [VerfasserIn]   i
Titel:Replication in the mononuclear phagocyte system (MPS) as a determinant of hantavirus pathogenicity
Verf.angabe:Martin J. Raftery, Pritesh Lalwani, Nina Lütteke, Lidija Kobak, Thomas Giese, Rainer G. Ulrich, Lukas Radosa, Detlev H. Krüger and Günther Schönrich
E-Jahr:2020
Jahr:12 June 2020
Umfang:14 S.
Fussnoten:Gesehen am 21.08.2020
Titel Quelle:Enthalten in: Frontiers in Cellular and Infection Microbiology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2020
Band/Heft Quelle:10(2020) Artikel-Nummer 281, 14 Seiten
ISSN Quelle:2235-2988
Abstract:Members of different virus families including Hantaviridae cause viral hemorrhagic fevers (VHFs). The decisive determinants of hantavirus-associated pathogenicity are still enigmatic. Pathogenic hantavirus species such as Puumala virus (PUUV), Hantaan virus (HTNV), Dobrava virus (DOBV), and Sin Nombre virus (SNV), are associated with significant case fatality rates. In contrast, Tula virus (TULV) only sporadically causes mild disease in immunocompetent humans and Prospect Hill virus (PHV) so far has not been associated with any symptoms. They are thus defined here as low pathogenic/apathogenic hantavirus species. We found that productive infection of cells of the mononuclear phagocyte system (MPS) such as monocytes and dendritic cells (DCs), correlated well with the pathogenicity of hantavirus species tested. HTNV (intermediate case fatality rates) replicated more efficiently than PUUV (low case fatality rates) in myeloid cells, whereas low pathogenic/apathogenic hantavirus species did not produce any detectable virus titers. Analysis of PHPUV, a reassortant hantavirus derived from a pathogenic (PUUV) and an apathogenic (PHV) hantavirus species, indicated that the viral glycoproteins are not decisive for replication in MPS cells. Moreover, blocking acidification of endosomes with chloroquine decreased the number of TULV genomes in myeloid cells suggesting a post-entry block for low pathogenic/apathogenic hantavirus species in myeloid cells. Intriguingly, pathogenic but not low pathogenic/apathogenic hantavirus species induced conversion of monocytes into inflammatory DCs. The proinflammatory programming of MPS cells by pathogenic hantavirus species required integrin signaling and viral replication. Our findings indicate that the capacity to replicate in MPS cells is a prominent feature of hantaviral pathogenicity.
DOI:doi:10.3389/fcimb.2020.00281
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3389/fcimb.2020.00281
 Volltext: https://www.frontiersin.org/articles/10.3389/fcimb.2020.00281/full
 DOI: https://doi.org/10.3389/fcimb.2020.00281
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Dendritic Cells
 Hantavirus
 Immunopathogenesis
 Monocytes
 viral pathogenesis
K10plus-PPN:1727581997
Verknüpfungen:→ Zeitschrift

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