Atherogenesis and iron

• Verfasst von: Vinchi, Francesca [VerfasserIn]
• Verfasst von: Muckenthaler, Martina [VerfasserIn]
• Verfasst von: Costa da Silva, Milene [VerfasserIn]
• Verfasst von: Balla, György [VerfasserIn]
• Verfasst von: Balla, József [VerfasserIn]
• Verfasst von: Jeney, Viktória [VerfasserIn]
• Titel: Atherogenesis and iron
• Titelzusatz: from epidemiology to cellular level
• Verf.angabe: Francesca Vinchi, Martina U. Muckenthaler, Milene C. Da Silva, György Balla, József Balla and Viktória Jeney
• E-Jahr: 2014
• Jahr: 05 May 2014
• Umfang: 20 S.
• Fussnoten: Gesehen am 24.08.2020
• Titel Quelle: Enthalten in: Frontiers in pharmacology
• Ort Quelle: Lausanne : Frontiers Media, 2010
• Jahr Quelle: 2014
• Band/Heft Quelle: 5(2014) Artikel-Nummer 94, 20 Seiten
• ISSN Quelle: 1663-9812
• DOI: doi:10.3389/fphar.2014.00094
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Atherosclerosis
• Sach-SW: Heme
• Sach-SW: Hemoglobin
• Sach-SW: intraplaque hemorrhage
• Sach-SW: Iron
• Sach-SW: LDL
• Sach-SW: Macrophages
• Sach-SW: Oxidative Stress
• K10plus-PPN: 1727697022

Abstract

Iron accumulates in human atherosclerotic lesions but whether it is a cause or simply a downstream consequence of the atheroma formation has been an open question for decades. According to the so called “iron hypothesis”, iron is believed to be detrimental for the cardiovascular system, thus promoting atherosclerosis development and progression. Iron, in its catalytically active form, can participate in the generation of reactive oxygen species and induce lipid-peroxidation, triggering endothelial activation, smooth muscle cell proliferation and macrophage activation; all of these processes are considered to be proatherogenic. On the other hand, the observation that hemochromatotic patients, affected by life-long iron overload, do not show any increased incidence of atherosclerosis is perceived as the most convincing evidence against the “iron hypothesis”. Epidemiological studies and data from animal models provided conflicting evidences about the role of iron in atherogenesis. Therefore more careful studies are needed in which issues like the source and the compartmentalization of iron will be addressed. This review article summarizes what we have learnt about iron and atherosclerosis from epidemiological studies, animal models and cellular systems and highlights the rather contributory than innocent role of iron in atherogenesis.