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Verfasst von:Vinchi, Francesca [VerfasserIn]   i
 Muckenthaler, Martina [VerfasserIn]   i
 Costa da Silva, Milene [VerfasserIn]   i
 Balla, György [VerfasserIn]   i
 Balla, József [VerfasserIn]   i
 Jeney, Viktória [VerfasserIn]   i
Titel:Atherogenesis and iron
Titelzusatz:from epidemiology to cellular level
Verf.angabe:Francesca Vinchi, Martina U. Muckenthaler, Milene C. Da Silva, György Balla, József Balla and Viktória Jeney
E-Jahr:2014
Jahr:05 May 2014
Umfang:20 S.
Fussnoten:Gesehen am 24.08.2020
Titel Quelle:Enthalten in: Frontiers in pharmacology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2014
Band/Heft Quelle:5(2014) Artikel-Nummer 94, 20 Seiten
ISSN Quelle:1663-9812
Abstract:Iron accumulates in human atherosclerotic lesions but whether it is a cause or simply a downstream consequence of the atheroma formation has been an open question for decades. According to the so called “iron hypothesis”, iron is believed to be detrimental for the cardiovascular system, thus promoting atherosclerosis development and progression. Iron, in its catalytically active form, can participate in the generation of reactive oxygen species and induce lipid-peroxidation, triggering endothelial activation, smooth muscle cell proliferation and macrophage activation; all of these processes are considered to be proatherogenic. On the other hand, the observation that hemochromatotic patients, affected by life-long iron overload, do not show any increased incidence of atherosclerosis is perceived as the most convincing evidence against the “iron hypothesis”. Epidemiological studies and data from animal models provided conflicting evidences about the role of iron in atherogenesis. Therefore more careful studies are needed in which issues like the source and the compartmentalization of iron will be addressed. This review article summarizes what we have learnt about iron and atherosclerosis from epidemiological studies, animal models and cellular systems and highlights the rather contributory than innocent role of iron in atherogenesis.
DOI:doi:10.3389/fphar.2014.00094
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3389/fphar.2014.00094
 Volltext: https://www.frontiersin.org/articles/10.3389/fphar.2014.00094/full
 DOI: https://doi.org/10.3389/fphar.2014.00094
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Atherosclerosis
 Heme
 Hemoglobin
 intraplaque hemorrhage
 Iron
 LDL
 Macrophages
 Oxidative Stress
K10plus-PPN:1727697022
Verknüpfungen:→ Zeitschrift

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