Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis

• Verfasst von: Seeßle, Jessica [VerfasserIn]
• Verfasst von: Gan-Schreier, Hongying [VerfasserIn]
• Verfasst von: Kirchner, Marietta [VerfasserIn]
• Verfasst von: Stremmel, Wolfgang [VerfasserIn]
• Verfasst von: Chamulitrat, Walee [VerfasserIn]
• Verfasst von: Merle, Uta [VerfasserIn]
• Titel: Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis
• Verf.angabe: Jessica Seeßle, Hongying Gan-Schreier, Marietta Kirchner, Wolfgang Stremmel, Walee Chamulitrat and Uta Merle
• E-Jahr: 2020
• Jahr: 17 July 2020
• Fussnoten: Gesehen am 25.08.2020
• Titel Quelle: Enthalten in: BMC gastroenterology
• Ort Quelle: London : BioMed Central, 2001
• Jahr Quelle: 2020
• Band/Heft Quelle: 20(2020) Artikel-Nummer 230, 9 Seiten
• ISSN Quelle: 1471-230X
• DOI: doi:10.1186/s12876-020-01282-3
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1727721101

Abstract

Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption and therefore iron Overload. iron overload leads to increased levels of toxic non-transferrin bound iron which results in oxidative stress and lipid peroxidation. The impact of iron on lipid metabolism is so far not fully understood. The aim of this study was to investigate lipid metabolism including lipoproteins (HDL, LDL), neutral (triglycerides, cholesterol) and polar lipids (sphingo- and phospholipids), and PNPLA3 polymorphism (rs738409/I148M) in HH.