Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Sun, Li [VerfasserIn]  |
| Wolferts, Guido Peter Maximilian [VerfasserIn]  |
| Veltkamp, Roland [VerfasserIn]  |
Titel: | Oxygen therapy does not increase production and damage induced by reactive oxygen species in focal cerebral ischemia |
Verf.angabe: | Li Sun, Guido Wolferts, Roland Veltkamp |
E-Jahr: | 2014 |
Jahr: | 5 June 2014 |
Umfang: | 5 S. |
Fussnoten: | Gesehen am 26.08.2020 |
Titel Quelle: | Enthalten in: Neuroscience letters |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
Jahr Quelle: | 2014 |
Band/Heft Quelle: | 577(2014), Seite 1-5 |
ISSN Quelle: | 1872-7972 |
Abstract: | Oxygen therapy with hyperbaric oxygen (HBO) or normobaric hyperoxia (NBO) improves outcome in experimental cerebral ischemia. However, an increased formation of reactive oxygen species (ROS) may be an undesirable side effect of oxygen therapy. We investigated the effect of both oxygen therapies on ROS production and adverse effects in murine focal ischemia. 25min after 90min filament-induced middle cerebral artery occlusion (MCAO), mice breathed either air, 100% O2 (NBO), or 100% O2 at 3 ata (HBO) for 60min. ROS were depicted on tissue sections after preischemic injection of hydroethidine, a marker of in vivo superoxide production. Moreover, infarct sizes were quantified in experiments using peroxybutinitrite (PBN) in mice treated with HBO. Effects of oxygen therapy were also tested in superoxide 2 knock-out mice. Both NBO and HBO significantly reduced superoxide radicals compared to air. Application of PBN had no additional protective effect when combined with HBO. Infarct volumes did not differ among SOD2 knock-out mice receiving air (34.0±19.6mm3), NBO (35.4±14.3mm3) or HBO (33.4±12.2mm3). In conclusion, brief episodes of oxygen therapy do not appear to promote damage inflicted by ROS in experimental stroke. |
DOI: | doi:10.1016/j.neulet.2014.05.060 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.neulet.2014.05.060 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0304394014004601 |
| DOI: https://doi.org/10.1016/j.neulet.2014.05.060 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Cerebral ischemia |
| HBO |
| Oxygen therapy |
| Reactive oxygen species |
| SOD2 |
K10plus-PPN: | 1727782100 |
Verknüpfungen: | → Zeitschrift |
Oxygen therapy does not increase production and damage induced by reactive oxygen species in focal cerebral ischemia / Sun, Li [VerfasserIn]; 5 June 2014 (Online-Ressource)
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