Metabolites regulate cell signaling and growth via covalent modification of proteins

• Verfasst von: Figlia, Gianluca [VerfasserIn]
• Verfasst von: Willnow, Philipp [VerfasserIn]
• Verfasst von: Teleman, Aurelio A. [VerfasserIn]
• Titel: Metabolites regulate cell signaling and growth via covalent modification of proteins
• Verf.angabe: Gianluca Figlia, Philipp Willnow, and Aurelio A. Teleman
• E-Jahr: 2020
• Jahr: July 20, 2020
• Umfang: 15 S.
• Fussnoten: Gesehen am 26.08.2020
• Titel Quelle: Enthalten in: Developmental cell
• Ort Quelle: Cambridge, Mass. : Cell Press, 2001
• Jahr Quelle: 2020
• Band/Heft Quelle: 54(2020), 2, Seite 156-170
• ISSN Quelle: 1878-1551
• DOI: doi:10.1016/j.devcel.2020.06.036
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: acetylation
• Sach-SW: autophagy
• Sach-SW: crotonylation
• Sach-SW: glutathionylation
• Sach-SW: hippo
• Sach-SW: malonylation
• Sach-SW: methylation
• Sach-SW: mTORC1
• Sach-SW: O-GlcNAc
• Sach-SW: palmitoylation
• Sach-SW: YAP
• K10plus-PPN: 1727816463

Abstract

Metabolites affect cell growth in two different ways. First, they serve as building blocks for biomass accumulation. Second, metabolites regulate the activity of growth-relevant signaling pathways. They do so in part by covalently attaching to proteins, thereby generating post-translational modifications (PTMs) that affect protein function, the focus of this Perspective. Recent advances in mass spectrometry have revealed a wide variety of such metabolites, including lipids, amino acids, Coenzyme-A, acetate, malonate, and lactate to name a few. An active area of research is to understand which modifications affect protein function and how they do so. In many cases, the cellular levels of these metabolites affect the stoichiometry of the corresponding PTMs, providing a direct link between cell metabolism and the control of cell signaling, transcription, and cell growth.