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Verfasst von:Bohaumilitzky, Lena [VerfasserIn]   i
 Knebel Doeberitz, Magnus von [VerfasserIn]   i
 Kloor, Matthias [VerfasserIn]   i
 Ahadova, Aysel [VerfasserIn]   i
Titel:Implications of hereditary origin on the immune phenotype of mismatch repair-deficient cancers
Titelzusatz:systematic literature review
Verf.angabe:Lena Bohaumilitzky, Magnus von Knebel Doeberitz, Matthias Kloor and Aysel Ahadova
E-Jahr:2020
Jahr:4 June 2020
Umfang:20 S.
Fussnoten:Gesehen am 26.08.2020
Titel Quelle:Enthalten in: Journal of Clinical Medicine
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2020
Band/Heft Quelle:9(2020), 6, Artikel-ID 1741, Seite 1-20
ISSN Quelle:2077-0383
Abstract:Microsatellite instability (MSI) represents one of the major types of genomic instability in human cancers and is most common in colorectal cancer (CRC) and endometrial cancer (EC). MSI develops as a consequence of DNA mismatch repair (MMR) deficiency, which can occur sporadically or in the context of Lynch syndrome (LS), the most common inherited tumor syndrome. MMR deficiency triggers the accumulation of high numbers of somatic mutations in the affected cells, mostly indel mutations at microsatellite sequences. MSI tumors are among the most immunogenic human tumors and are often characterized by pronounced local immune responses. However, so far, little is known about immunological differences between sporadic and hereditary MSI tumors. Therefore, a systematic literature search was conducted to comprehensively collect data on the differences in local T cell infiltration and immune evasion mechanisms between sporadic and LS-associated MSI tumors. The vast majority of collected studies were focusing on CRC and EC. Generally, more pronounced T cell infiltration and a higher frequency of B2M mutations were reported for LS-associated compared to sporadic MSI tumors. In addition, phenotypic features associated with enhanced lymphocyte recruitment were reported to be specifically associated with hereditary MSI CRCs. The quantitative and qualitative differences clearly indicate a distinct biology of sporadic and hereditary MSI tumors. Clinically, these findings underline the need for differentiating sporadic and hereditary tumors in basic science studies and clinical trials, including trials evaluating immune checkpoint blockade therapy in MSI tumors.
DOI:doi:10.3390/jcm9061741
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/jcm9061741
 kostenfrei: Volltext: https://www.mdpi.com/2077-0383/9/6/1741
 DOI: https://doi.org/10.3390/jcm9061741
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:colorectal cancer
 DNA mismatch repair deficiency
 immune evasion
 immune infiltration
 Lynch syndrome
 microsatellite instability
K10plus-PPN:1727826566
Verknüpfungen:→ Zeitschrift

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