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Verfasst von:Kocer, Kaan [VerfasserIn]   i
 Boutin, Sébastien [VerfasserIn]   i
 Dalpke, Alexander [VerfasserIn]   i
 Heeg, Klaus [VerfasserIn]   i
 Mutters, Nico T. [VerfasserIn]   i
 Nurjadi, Dennis [VerfasserIn]   i
Titel:Comparative genomic analysis reveals a high prevalence of inter-species in vivo transfer of carbapenem-resistance plasmids in patients with haematological malignancies
Verf.angabe:K. Kocer, S. Boutin, A.H. Dalpke, K. Heeg, N.T. Mutters, D. Nurjadi
Jahr:2020
Umfang:8 S.
Fussnoten:Available online 23 October 2019 ; Gesehen am 26.08.2020
Titel Quelle:Enthalten in: Clinical microbiology and infection
Ort Quelle:Oxford : Elsevier, 1995
Jahr Quelle:2020
Band/Heft Quelle:26(2020), 6, Seite 780.e1-780.e8
ISSN Quelle:1469-0691
Abstract:Objectives - Conjugative gene transfer has been considered as one of the driving factors in the transmission and dissemination of multidrug resistance in bacteria. The abundance of antimicrobial resistance genes and bacteria in the gut microbiome may provide the ideal platform for plasmid exchange. Systematic data on in vivo horizontal gene transfer (HGT) and its frequency are scarce. - Materials and methods - One hundred and ninety-six carbapenem-resistant gram-negative bacilli (CRGNBs) from 179 patients (158 inpatients and 21 outpatients) between January 2016 and April 2017 were analysed retrospectively. Alignment of plasmid content for 32 isolates from 16 patients with multiple CRGNB species was performed from whole-genome sequencing (WGS) data. - Results - Sixteen of the 179 patients (8.9%) were colonized and/or infected with more than one CRGNB species; 11/179 (6.1%) were colonized by multiple carbapenem-resistant Enterobacteriaceae (CREs) and 5/179 (2.8%) by carbapenem-resistant non-fermenters (CRNFs) and CREs. WGS suggested interspecies transfer as the predominant mechanism rather than independent acquisition in 8/10 patients (80%, one non-recoverable isolate) with multiple CREs but not in CRNF-CRE combinations; 30/158 inpatients (20%) had underlying haematological malignancies, and they are more likely to exhibit multiple CRGNB strains (OR 3.0, 95%CI 0.98-8.89, p 0.05) and CRE strains (OR 3.9, 95%CI 1.02-14.58, p 0.04) during hospital stay compared to other patient groups. - Conclusion - Our data give insight into the occurrence of natural in vivo HGT in a clinical setting. Better understanding of HGT will help optimize containment measures and may guide antibiotic stewardship programmes.
DOI:doi:10.1016/j.cmi.2019.10.014
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.cmi.2019.10.014
 Volltext: http://www.sciencedirect.com/science/article/pii/S1198743X19305488
 DOI: https://doi.org/10.1016/j.cmi.2019.10.014
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Antibiotic resistance
 Carbapenem-resistant gram negatives
 Enterobacteriaceae
 Multidrug resistance
 Plasmid transfer
 WGS
K10plus-PPN:1727835050
Verknüpfungen:→ Zeitschrift

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