| |  Online-Ressource |
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| Verfasst von: | Watson, Anna M. D. [VerfasserIn]  |
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| | Li, Jiaze [VerfasserIn] |
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| | Samijono, Dian [VerfasserIn] |
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| | Bierhaus, Angelika [VerfasserIn] |
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| | Thomas, Merlin C. [VerfasserIn] |
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| | Jandeleit-Dahm, Karin A. M. [VerfasserIn] |
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| | Cooper, Mark E. [VerfasserIn] |
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| Titel: | Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice |
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| Verf.angabe: | Anna M.D. Watson, Jiaze Li, Dian Samijono, Angelika Bierhaus, Merlin C. Thomas, Karin A.M. Jandeleit-Dahm, Mark E. Cooper |
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| E-Jahr: | 2014 |
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| Jahr: | 4 June 2014 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 27.08.2020 |
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| Titel Quelle: | Enthalten in: Atherosclerosis |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1970 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 235(2014), 2, Seite 444-448 |
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| ISSN Quelle: | 1879-1484 |
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| Abstract: | Objective/Rationale - Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA. - Methods - Diabetic (5 × 55 mg/kg streptozotocin daily) and non-diabetic male RAGE/apolipoprotein E double knockout (RAGE/apoE DKO) mice were treated with quinapril (30 mg/kg/day) for 20 weeks. At the end of the study aortic plaques were assessed. - Results - Diabetic RAGE/apoE DKO showed significantly less plaque area than diabetic apoE KO mice. Plaque deposition was almost abolished in quinapril treated diabetic RAGE/apoE DKOs, with significant attenuation of vascular collagen deposition, nitrotyrosine staining, and reduced macrophage infiltration. Expression of the advanced glycation end product receptor 3 (galectin 3) was also significantly reduced. - Conclusion - Concomitant inhibition of RAS and RAGE signalling almost completely inhibited the development of experimental DAA. A dual therapeutic approach may be a superior strategy for the treatment of diabetic macrovascular disease.. |
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| DOI: | doi:10.1016/j.atherosclerosis.2014.05.945 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.atherosclerosis.2014.05.945 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0021915014012088 |
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| | DOI: https://doi.org/10.1016/j.atherosclerosis.2014.05.945 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | AGEs |
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| | Atherosclerosis |
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| | Experimental diabetes |
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| | Mouse model |
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| | RAGE |
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| K10plus-PPN: | 1727876989 |
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| Verknüpfungen: | → Zeitschrift |
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Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice / Watson, Anna M. D. [VerfasserIn]; 4 June 2014 (Online-Ressource)
