Efficient and automated large-scale detection of structural relationships in proteins with a flexible aligner

• Verfasst von: Gutiérrez, Fernando I. [VerfasserIn]
• Verfasst von: Rodriguez-Valenzuela, Felipe [VerfasserIn]
• Verfasst von: Ibarra, Ignacio L. [VerfasserIn]
• Verfasst von: Devos, Damien [VerfasserIn]
• Verfasst von: Melo, Francisco [VerfasserIn]
• Titel: Efficient and automated large-scale detection of structural relationships in proteins with a flexible aligner
• Verf.angabe: Fernando I. Gutiérrez, Felipe Rodriguez-Valenzuela, Ignacio L. Ibarra, Damien P. Devos and Francisco Melo
• E-Jahr: 2016
• Jahr: 05 January 2016
• Umfang: 13 S.
• Fussnoten: Gesehen am 28.08.2020
• Titel Quelle: Enthalten in: BMC bioinformatics
• Ort Quelle: London : BioMed Central, 2000
• Jahr Quelle: 2016
• Band/Heft Quelle: 17(2016) Artikel-Nummer 20, 13 Seiten
• ISSN Quelle: 1471-2105
• DOI: doi:10.1186/s12859-015-0866-8
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1727960114

Abstract

The total number of known three-dimensional protein structures is rapidly increasing. Consequently, the need for fast structural search against complete databases without a significant loss of accuracy is increasingly demanding. Recently, TopSearch, an ultra-fast method for finding rigid structural relationships between a query structure and the complete Protein Data Bank (PDB), at the multi-chain level, has been released. However, comparable accurate flexible structural aligners to perform efficient whole database searches of multi-domain proteins are not yet available. The availability of such a tool is critical for a sustainable boosting of biological discovery.