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| Verfasst von: | Kender, Zoltán [VerfasserIn]  |
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| | Fleming, Thomas [VerfasserIn] |
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| | Kopf, Stefan [VerfasserIn] |
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| | Torzsa, P. [VerfasserIn] |
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| | Grolmusz, V. [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| | Schleicher, E. [VerfasserIn] |
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| | Rácz, K. [VerfasserIn] |
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| | Reismann, P. [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| Titel: | Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes |
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| Verf.angabe: | Z. Kender, T. Fleming, S. Kopf, P. Torzsa, V. Grolmusz, S. Herzig, E. Schleicher, K. Rácz, P. Reismann, P.P. Nawroth |
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| E-Jahr: | 2014 |
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| Jahr: | 07. April 2014 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 28.08.2020 |
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| Titel Quelle: | Enthalten in: Experimental and clinical endocrinology & diabetes |
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| Ort Quelle: | Stuttgart [u.a.] : Thieme, 1983 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 122(2014), 5, Seite 316-319 |
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| ISSN Quelle: | 1439-3646 |
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| Abstract: | The effect of metformin on methylglyoxal (MG) metabolism was studied in a prospective non-randomized 24 weeks trial in patients with type 2 diabetes. Metformin treatment, in addition to life style intervention, significantly reduced morning glucose and HbA1c whilst body weight and BMI were only marginally reduced during the 24 week trial. Treatment significantly reduced both plasma MG and carboxymethyl-lysine (CML), a marker of oxidative stress. The reduction in MG was paralleled by a significant increase in the activity of Glyoxalase 1 (Glo1), the major route of MG detoxification, in peripheral blood mononuclear cells and red blood cells. Multivariate analysis showed that the changes in MG were dependent upon the metformin treatment. This study supports previous findings that metformin can reduce plasma MG in type 2 diabetic patients. However, given the observed increase in Glo1 activity, this reduction is due not only to the scavenging properties of metformin, but the restoration of Glo1 activity. |
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| DOI: | doi:10.1055/s-0034-1371818 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1055/s-0034-1371818 |
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| | Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1371818 |
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| | DOI: https://doi.org/10.1055/s-0034-1371818 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1727997093 |
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| Verknüpfungen: | → Zeitschrift |
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Effect of metformin on methylglyoxal metabolism in patients with type 2 diabetes / Kender, Zoltán [VerfasserIn]; 07. April 2014 (Online-Ressource)
