Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content

• Verfasst von: Guerrero-Hernández, Agustín [VerfasserIn]
• Verfasst von: Sánchez-Vázquez, Víctor Hugo [VerfasserIn]
• Verfasst von: Martínez-Martínez, Ericka [VerfasserIn]
• Verfasst von: Sandoval-Vázquez, Lizeth [VerfasserIn]
• Verfasst von: Perez-Rosas, Norma C. [VerfasserIn]
• Verfasst von: Lopez-Farias, Rodrigo [VerfasserIn]
• Verfasst von: Dagnino-Acosta, Adan [VerfasserIn]
• Titel: Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content
• Verf.angabe: Agustín Guerrero-Hernández, Víctor Hugo Sánchez-Vázquez, Ericka Martínez-Martínez, Lizeth Sandoval-Vázquez, Norma C. Perez-Rosas, Rodrigo Lopez-Farias, Adan Dagnino-Acosta
• E-Jahr: 2019
• Jahr: 24 October 2019
• Umfang: 34 S.
• Teil: year:2019
• Teil: pages:337-370
• Teil: extent:34
• Fussnoten: Gesehen am 31.08.2020
• Titel Quelle: Enthalten in: Calcium signaling
• Ausgabe Quelle: Second edition
• Ort Quelle: Cham : Springer, 2019
• Jahr Quelle: 2019
• Band/Heft Quelle: (2019), Seite 337-370
• ISBN Quelle: 978-3-030-12457-1
• DOI: doi:10.1007/978-3-030-12457-1_14
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Calcium buffer capacity
• Sach-SW: Endoplasmic reticulum (ER)
• Sach-SW: IP3 receptors (IP3Rs)
• Sach-SW: Kinetics on demand (KonD)
• Sach-SW: Ryanodine receptors (RyRs)
• Sach-SW: Sarco-endoplasmic reticulum calcium ATPase (SERCA pump)
• Sach-SW: Sarcoplasmic reticulum (SR)
• K10plus-PPN: 1728074932

Abstract

The sarcoplasmic/endoplasmic reticulum (SR/ER) is the main intracellular calcium (Ca2+) pool in muscle and non-muscle eukaryotic cells, respectively. The reticulum accumulates Ca2+ against its electrochemical gradient by the action of sarco/endoplasmic reticulum calcium ATPases (SERCA pumps), and the capacity of this Ca2+ store is increased by the presence of Ca2+ binding proteins in the lumen of the reticulum. A diversity of physical and chemical signals, activate the main Ca2+ release channels, i.e. ryanodine receptors (RyRs) and inositol (1, 4, 5) trisphosphate receptors (IP3Rs), to produce transient elevations of the cytoplasmic calcium concentration ([Ca2+]i) while the reticulum is being depleted of Ca2+. This picture is incomplete because it implies that the elements involved in the Ca2+ release process are acting alone and independently of each other. However, it appears that the Ca2+ released by RyRs and IP3Rs is trapped in luminal Ca2+ binding proteins (Ca2+ lattice), which are associated with these release channels, and the activation of these channels appears to facilitate that the trapped Ca2+ ions become available for release. This situation makes the initial stage of the Ca2+ release process a highly efficient one; accordingly, there is a large increase in the [Ca2+]i with minimal reductions in the bulk of the free luminal SR/ER [Ca2+] ([Ca2+]SR/ER). Additionally, it has been shown that active SERCA pumps are required for attaining this highly efficient Ca2+ release process. All these data indicate that Ca2+ release by the SR/ER is a highly regulated event and not just Ca2+ coming down its electrochemical gradient via the open release channels. One obvious advantage of this sophisticated Ca2+ release process is to avoid depletion of the ER Ca2+ store and accordingly, to prevent the activation of ER stress during each Ca2+ release event.