| |  Online-Ressource |
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| Verfasst von: | Meyer, Andreas [VerfasserIn]  |
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| | Oehninger, Luciano [VerfasserIn] |
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| | Geldmacher, Yvonne [VerfasserIn] |
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| | Alborzinia, Hamed [VerfasserIn] |
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| | Wölfl, Stefan [VerfasserIn] |
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| | Sheldrick, William S. [VerfasserIn] |
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| | Ott, Ingo [VerfasserIn] |
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| Titel: | Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators |
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| Verf.angabe: | Andreas Meyer, Luciano Oehninger, Yvonne Geldmacher, Hamed Alborzinia, Stefan Wölfl, William S. Sheldrick, and Ingo Ott |
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| E-Jahr: | 2014 |
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| Jahr: | May 6, 2014 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 01.09.2020 |
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| Titel Quelle: | Enthalten in: ChemMedChem |
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| Ort Quelle: | Weinheim [u.a.] : Wiley-VCH, 2006 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 9(2014), 8, Seite 1794-1800 |
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| ISSN Quelle: | 1860-7187 |
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| Abstract: | Abstract Organometallic conjugates consisting of a gold(I) N-heterocyclic carbene (NHC) moiety and a naphthalimide were prepared and investigated as cytotoxic agents that interact with both DNA and the disulfide reductase enzyme thioredoxin reductase (TrxR). The complexes were potent DNA intercalators related to their naphthalimide partial structure, inhibited TrxR as a consequence of the incorporation of the gold(I) moiety, and triggered efficient cytotoxic effects in MCF-7 breast and HT-29 colon adenocarcinoma cells. Strong effects on tumor cell metabolism were noted for the most cytotoxic complex, chlorido[1-(3?-(4??-ethylthio-1??,8??-naphthalimid-N??-yl))-propyl-3-methyl-imidazol-2-ylidene]gold(I) (4?d). In conclusion, the conjugation of naphthalimides with gold(I) NHC moieties provided a useful strategy for the design of bioorganometallic anticancer agents with multiple modes of action. |
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| DOI: | doi:10.1002/cmdc.201402049 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/cmdc.201402049 |
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| | Volltext: https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.201402049 |
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| | DOI: https://doi.org/10.1002/cmdc.201402049 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | DNA |
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| | gold |
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| | N-heterocyclic carbenes |
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| | naphthalimides |
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| | thioredoxin reductase |
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| K10plus-PPN: | 1728239249 |
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| Verknüpfungen: | → Zeitschrift |
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Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators / Meyer, Andreas [VerfasserIn]; May 6, 2014 (Online-Ressource)
