Status: Bibliographieeintrag
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| Verfasst von: | Schneeweiss, Andreas [VerfasserIn]  |
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| | Seitz, Julia [VerfasserIn] |
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| | Smetanay, Katharina [VerfasserIn] |
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| | Schütz, Florian [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Zorn, Markus [VerfasserIn] |
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| | Sinn, Peter [VerfasserIn] |
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| | Marmé, Frederik [VerfasserIn] |
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| Titel: | Efficacy of nab-paclitaxel does not seem to be associated with SPARC expression in metastatic breast cancer |
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| Verf.angabe: | Andreas Schneeweiss, Julia Seitz, Katharina Smetanay, Florian Schuetz, Dirk Jaeger, Andreas Bachinger, Markus Zorn, Hans-Peter Sinn and Frederik Marmé |
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| E-Jahr: | 2014 |
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| Jahr: | August 4, 2014 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 01.09.2020 |
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| Titel Quelle: | Enthalten in: Anticancer research |
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| Ort Quelle: | Attiki, 2004 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 34(2014), 11, Seite 6609-6615 |
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| ISSN Quelle: | 1791-7530 |
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| Abstract: | Aim: To evaluate the predictive value of the expression of the secreted protein acidic and rich in cysteine (SPARC) for nab-paclitaxel in metastatic breast cancer (MBC). Patients and Methods: Forty-four patients with progressive MBC were prospectively treated with nab-paclitaxel. Expression of SPARC in tumor cells was assessed by an immunoreactive score, integrating staining intensity and percentage of positive tumor cells; expression in stroma based on staining intensity. SPARC serum levels were determined before 1st and 2nd cycle of nab-paclitaxel and at progression. By applying several cut-offs the association between SPARC expression or serum levels and clinical end-points was analyzed. Results: No clear association between expression of SPARC in primary or metastatic tumor tissue or in serum and any clinical end-point could be detected regardless of the various cut-offs applied. Conclusion: Efficacy of nab-paclitaxel in MBC does not seem to be associated with expression of SPARC in tumor tissues or serum. |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://ar.iiarjournals.org/content/34/11/6609 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chemotherapy |
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| | Metastatic breast cancer |
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| | nab-paclitaxel |
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| | SPARC |
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| K10plus-PPN: | 1728500427 |
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| Verknüpfungen: | → Zeitschrift |
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Efficacy of nab-paclitaxel does not seem to be associated with SPARC expression in metastatic breast cancer / Schneeweiss, Andreas [VerfasserIn]; August 4, 2014 (Online-Ressource)
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