Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women

• Verfasst von: Lerchbaum, Elisabeth [VerfasserIn]
• Verfasst von: Schwetz, Verena [VerfasserIn]
• Verfasst von: Giuliani, Albrecht [VerfasserIn]
• Verfasst von: Obermayer-Pietsch, Barbara [VerfasserIn]
• Titel: Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women
• Verf.angabe: Elisabeth Lerchbaum, Verena Schwetz, Albrecht Giuliani and Barbara Obermayer-Pietsch
• E-Jahr: 2014
• Jahr: May 2014
• Umfang: 13 S.
• Fussnoten: Gesehen am 01.09.2020
• Titel Quelle: Enthalten in: European journal of endocrinology
• Ort Quelle: Bristol : BioScientifica Ltd., 1948
• Jahr Quelle: 2014
• Band/Heft Quelle: 170(2014), 5, Seite 727-739
• ISSN Quelle: 1479-683X
• DOI: doi:10.1530/EJE-13-1035
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 172850371X

Abstract

<section class="abstract"><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e3">Objective</h3><p>There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We aim to study the metabolic and endocrine characteristics of PCOS women with and without a family history (FHx) of type 2 diabetes mellitus (T2DM) and PCOS.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e6">Design</h3><p>Cross-sectional study.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e9">Methods</h3><p>We analysed the association of T2DM FHx and PCOS FHx with metabolic and endocrine parameters in 714 PCOS women.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e12">Results</h3><p>A positive FHx of T2DM and PCOS were prevalent in 36.8 and 21.4% of PCOS women respectively. We found an independent association of T2DM FHx with central fat accumulation, obesity, prediabetes, metabolic syndrome (MS), insulin resistance, low HDL and elevated blood pressure (<em>P</em>&lt;0.05 for all). PCOS FHx was independently associated with prediabetes (<em>P</em>&lt;0.05). We observed an independent association of PCOS FHx with clinical and biochemical hyperandrogenism (<em>P</em>&lt;0.05 for all), whereas there was no independent association of T2DM FHx with hyperandrogenism. PCOS women with a positive FHx of both T2DM and PCOS had an adverse metabolic and endocrine profile including a linear increase in risk of obesity, central fat accumulation, MS, prediabetes and low HDL (<em>P</em>&lt;0.05 for all).</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e24">Conclusions</h3><p>Our findings suggest that the assessment of FHx might allow risk stratification of PCOS women, which is important considering the high prevalence of PCOS.</p></div></section>