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Status: Bibliographieeintrag

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Verfasst von:Luo, Yanxin [VerfasserIn]   i
 Wong, Chao-Jen [VerfasserIn]   i
 Kaz, Andrew M. [VerfasserIn]   i
 Dzieciatkowski, Slavomir [VerfasserIn]   i
 Carter, Kelly T. [VerfasserIn]   i
 Morris, Shelli M. [VerfasserIn]   i
 Wang, Jianping [VerfasserIn]   i
 Willis, Joseph E. [VerfasserIn]   i
 Makar, Karen W. [VerfasserIn]   i
 Ulrich, Cornelia [VerfasserIn]   i
 Lutterbaugh, James D. [VerfasserIn]   i
 Shrubsole, Martha J. [VerfasserIn]   i
 Zheng, Wei [VerfasserIn]   i
 Markowitz, Sanford D. [VerfasserIn]   i
 Grady, William M. [VerfasserIn]   i
Titel:Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer
Verf.angabe:Yanxin Luo, Chao-Jen Wong, Andrew M. Kaz, Slavomir Dzieciatkowski, Kelly T. Carter, Shelli M. Morris, Jianping Wang, Joseph E. Willis, Karen W. Makar, Cornelia M. Ulrich, James D. Lutterbaugh, Martha J. Shrubsole, Wei Zheng, Sanford D. Markowitz, and William M. Grady
E-Jahr:2014
Jahr:30 April 2014
Umfang:20 S.
Fussnoten:Gesehen am 02.09.2020
Titel Quelle:Enthalten in: Gastroenterology
Ort Quelle:Stanford, Calif. : HighWire Press, 1965
Jahr Quelle:2014
Band/Heft Quelle:147(2014), 2, Seite 418-429,e1-e8
ISSN Quelle:1528-0012
Abstract:Background & Aims - Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenetic and genetic alterations have been detected in conventional tubular adenomas, little is known about how these affect progression to CRC. We compared methylomes of normal colon mucosa, tubular adenomas, and colorectal cancers to determine how epigenetic alterations might contribute to cancer formation. - Methods - We conducted genome-wide array-based studies and comprehensive data analyses of aberrantly methylated loci in 41 normal colon tissue, 42 colon adenomas, and 64 cancers using HumanMethylation450 arrays. - Results - We found genome-wide alterations in DNA methylation in the nontumor colon mucosa and cancers. Three classes of cancers and 2 classes of adenomas were identified based on their DNA methylation patterns. The adenomas separated into classes of high-frequency methylation and low-frequency methylation. Within the high-frequency methylation adenoma class a subset of adenomas had mutant KRAS. Additionally, the high-frequency methylation adenoma class had DNA methylation signatures similar to those of cancers with low or intermediate levels of methylation, and the low-frequency methylation adenoma class had methylation signatures similar to that of nontumor colon tissue. The CpG sites that were differentially methylated in these signatures are located in intragenic and intergenic regions. - Conclusions - Genome-wide alterations in DNA methylation occur during early stages of progression of tubular adenomas to cancer. These findings reveal heterogeneity in the pathogenesis of colorectal cancer, even at the adenoma step of the process.
DOI:doi:10.1053/j.gastro.2014.04.039
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1053/j.gastro.2014.04.039
 Volltext: http://www.sciencedirect.com/science/article/pii/S0016508514005952
 DOI: https://doi.org/10.1053/j.gastro.2014.04.039
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Colon Cancer
 Epigenetic Modifications
 Gene Regulation
 Progression
K10plus-PPN:1728580897
Verknüpfungen:→ Zeitschrift

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