| |  Online-Ressource |
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| Verfasst von: | Knodel, Markus M. [VerfasserIn]  |
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| | Geiger, Romina [VerfasserIn] |
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| | Ge, Lihao [VerfasserIn] |
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| | Bucher, Daniel [VerfasserIn] |
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| | Grillo, Alfio [VerfasserIn] |
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| | Wittum, Gabriel [VerfasserIn] |
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| | Schuster, Christoph M. [VerfasserIn] |
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| | Queisser, Sean Gillian [VerfasserIn] |
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| Titel: | Synaptic bouton properties are tuned to best fit the prevailing firing pattern |
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| Verf.angabe: | Markus M. Knodel, Romina Geiger, Lihao Ge, Daniel Bucher, Alfio Grillo, Gabriel Wittum, Christoph M. Schuster and Gillian Queisser |
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| E-Jahr: | 2014 |
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| Jahr: | 09 September 2014 |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 03.09.2020 |
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| Titel Quelle: | Enthalten in: Frontiers in computational neuroscience |
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| Ort Quelle: | Lausanne : Frontiers Research Foundation, 2007 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 8(2014) Artikel-Nummer 101, 16 Seiten |
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| ISSN Quelle: | 1662-5188 |
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| Abstract: | The morphology of presynaptic specializations can vary greatly ranging from classical single-release-site boutons in the central nervous system to boutons of various sizes harboring multiple vesicle release sites. Multi-release-site boutons can be found in several neural contexts, for example at the neuromuscular junction (NMJ) of body wall muscles of Drosophila larvae. These NMJs are built by two motor neurons forming two types of glutamatergic multi-release-site boutons with two typical diameters. However, it is unknown why these distinct nerve terminal configurations are used on the same postsynaptic muscle fiber. To systematically dissect the biophysical properties of these boutons we developed a full three-dimensional model of such boutons, their release sites and transmitter-harboring vesicles and analyzed the local vesicle dynamics of various configurations during stimulation. Here we show that the rate of transmission of a bouton is primarily limited by diffusion-based vesicle movements and that the probability of vesicle release and the size of a bouton affect bouton-performance in distinct temporal domains allowing for an optimal transmission of the neural signals at different time scales. A comparison of our in silico simulations with in vivo recordings of the natural motor pattern of both neurons revealed that the bouton properties resemble a well-tuned cooperation of the parameters release probability and bouton size, enabling a reliable transmission of the prevailing firing-pattern at diffusion-limited boutons. Our findings indicate that the prevailing firing-pattern of a neuron may determine the physiological and morphological parameters required for its synaptic terminals. |
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| DOI: | doi:10.3389/fncom.2014.00101 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3389/fncom.2014.00101 |
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| | Volltext: https://www.frontiersin.org/articles/10.3389/fncom.2014.00101/full |
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| | DOI: https://doi.org/10.3389/fncom.2014.00101 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adaption |
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| | boutons |
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| | firing pattern |
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| | Modeling and Simulation |
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| | morphology |
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| | Neuromuscular Junction |
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| | structure-function relationships |
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| K10plus-PPN: | 1728773806 |
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| Verknüpfungen: | → Zeitschrift |
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Synaptic bouton properties are tuned to best fit the prevailing firing pattern / Knodel, Markus M. [VerfasserIn]; 09 September 2014 (Online-Ressource)
