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Status: Bibliographieeintrag

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Verfasst von:Wölfl, Christoph Georg [VerfasserIn]   i
 Schweppenhäuser, Daniela [VerfasserIn]   i
 Gühring, Thorsten [VerfasserIn]   i
 Takur, Caner [VerfasserIn]   i
 Höner, Bernd [VerfasserIn]   i
 Kneser, Ulrich [VerfasserIn]   i
 Grützner, Paul Alfred [VerfasserIn]   i
 Harhaus-Wähner, Leila [VerfasserIn]   i
Titel:Characteristics of bone turnover in the long bone metaphysis fractured patients with normal or low bone mineral density (BMD)
Verf.angabe:Christoph Wölfl, Daniela Schweppenhäuser, Thorsten Gühring, Caner Takur, Bernd Höner, Ulrich Kneser, Paul Alfred Grützner, Leila Kolios
E-Jahr:2014
Jahr:May 1, 2014
Umfang:7 S.
Fussnoten:Gesehen am 04.09.2020
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2014
Band/Heft Quelle:9(2014,5) Artikel-Nummer e96058, 7 Seiten
ISSN Quelle:1932-6203
Abstract:The incidence of osteoporotic fractures increases as our population ages. Until now, the exact biochemical processes that occur during the healing of metaphyseal fractures remain unclear. Diagnostic instruments that allow a dynamic insight into the fracture healing process are as yet unavailable. In the present matched pair analysis, we study the time course of the osteoanabolic markers bone specific alkaline phosphatase (BAP) and transforming growth factor β1 (TGFβ1), as well as the osteocatabolic markers crosslinked C-telopeptide of type-I-collagen (β-CTX) and serum band 5 tartrate-resistant acid phosphatase (TRAP5b), during the healing of fractures that have a low level of bone mineral density (BMD) compared with fractures that have a normal BMD. Between March 2007 and February 2009, 30 patients aged older than 50 years who suffered a metaphyseal fracture were included in our study. BMDs were verified by dual energy Xray absorptiometry (DXEA) scans. The levels of BTMs were examined over an 8-week period. Osteoanabolic BAP levels in those with low levels of BMD were significantly different from the BAP levels in those with normal BMD. BAP levels in the former group increased constantly, whereas the latter group showed an initial strong decrease in BAP followed by slowly rising values. Osteocatabolic β-CTX increased in the bone of the normal BMD group constantly, whereas these levels decreased significantly in the bone of the group with low BMD from the first week. TRAP5b was significantly reduced in the low level BMD group. With this work, we conduct first insights into the molecular biology of the fracture healing process in patients with low levels of BMD that explains the mechanism of its fracture healing. The results may be one reason for the reduced healing qualities in bones with low BMD.
DOI:doi:10.1371/journal.pone.0096058
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0096058
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096058
 DOI: https://doi.org/10.1371/journal.pone.0096058
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Bone and mineral metabolism
 Bone density
 Bone development
 Bone fracture
 Bone remodeling
 Bone resorption
 Humerus
 Tissue repair
K10plus-PPN:1728908132
Verknüpfungen:→ Zeitschrift

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