| |  Online-Ressource |
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| Verfasst von: | Gorniak, Thomas [VerfasserIn]  |
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| | Haraszti, Tamás [VerfasserIn] |
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| | Suhonen, Heikki [VerfasserIn] |
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| | Yang, Yang [VerfasserIn] |
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| | Hedberg‐Buenz, Adam [VerfasserIn] |
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| | Koehn, Demelza [VerfasserIn] |
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| | Heine, Ruth [VerfasserIn] |
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| | Grunze, Michael [VerfasserIn] |
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| | Rosenhahn, Axel [VerfasserIn] |
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| | Anderson, Michael G. [VerfasserIn] |
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| Titel: | Support and challenges to the melanosomal casing model based on nanoscale distribution of metals within iris melanosomes detected by X-ray fluorescence analysis |
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| Verf.angabe: | Thomas Gorniak, Tamás Haraszti, Heikki Suhonen, Yang Yang, Adam Hedberg‐Buenz, Demelza Koehn, Ruth Heine, Michael Grunze, Axel Rosenhahn and Michael G. Anderson |
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| E-Jahr: | 2014 |
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| Jahr: | 5 June 2014 |
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| Umfang: | 4 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 04.09.2020 |
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| Titel Quelle: | Enthalten in: Pigment cell & melanoma research |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 2008 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 27(2014), 5, Seite 831-834 |
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| ISSN Quelle: | 1755-148X |
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| Abstract: | Melanin within melanosomes exists as eumelanin or pheomelanin. Distributions of these melanins have been studied extensively within tissues, but less often within individual melanosomes. Here, we apply X-ray fluorescence analysis with synchrotron radiation to survey the nanoscale distribution of metals within purified melanosomes of mice. The study allows a discovery-based characterization of melanosomal metals, and, because Cu is specifically associated with eumelanin, a hypothesis-based test of the ‘casing model’ predicting that melanosomes contain a pheomelanin core surrounded by a eumelanin shell. Analysis of Cu, Ca, and Zn shows variable concentrations and distributions, with Ca/Zn highly correlated, and at least three discrete patterns for the distribution of Cu vs. Ca/Zn in different melanosomes - including one with a Cu-rich shell surrounding a Ca/Zn-rich core. Thus, the results support predictions of the casing model, but also suggest that in at least some tissues and genetic contexts, other arrangements of melanin may co-exist. |
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| DOI: | doi:10.1111/pcmr.12278 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/pcmr.12278 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/pcmr.12278 |
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| | DOI: https://doi.org/10.1111/pcmr.12278 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | eumelanin |
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| | melanosome |
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| | metal |
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| | pheomelanin |
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| | synchrotron-based imaging |
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| | X-ray fluorescence analysis |
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| K10plus-PPN: | 1728911184 |
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| Verknüpfungen: | → Zeitschrift |
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Support and challenges to the melanosomal casing model based on nanoscale distribution of metals within iris melanosomes detected by X-ray fluorescence analysis / Gorniak, Thomas [VerfasserIn]; 5 June 2014 (Online-Ressource)
