| |  Online-Ressource |
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| Verfasst von: | Moreth, Kristin [VerfasserIn]  |
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| | Fischer, Ralf [VerfasserIn] |
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| | Fuchs, Helmut [VerfasserIn] |
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| | Gailus-Durner, Valérie [VerfasserIn] |
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| | Wurst, Wolfgang [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Bekeredjian, Raffi [VerfasserIn] |
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| | Hrabě de Angelis, Martin [VerfasserIn] |
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| Titel: | High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains |
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| Verf.angabe: | Kristin Moreth · Ralf Fischer · Helmut Fuchs · Valérie Gailus-Durner · Wolfgang Wurst · Hugo A. Katus · Raffi Bekeredjian · Martin Hrabě de Angelis |
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| E-Jahr: | 2014 |
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| Jahr: | 1 May 2014 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 07.09.2020 |
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| Titel Quelle: | Enthalten in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology |
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| Ort Quelle: | Berlin : Springer, 1984 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 184(2014), 6, Seite 763-775 |
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| ISSN Quelle: | 1432-136X |
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| Abstract: | Mice with genetic alterations are used in heart research as model systems of human diseases. In the last decade there was a marked increase in the recognition of genetic diversity within inbred mouse strains. Increasing numbers of inbred mouse strains and substrains and analytical variation of cardiac phenotyping methods require reproducible, high-throughput methods to standardize murine cardiovascular physiology. We describe methods for non-invasive, reliable, easy and fast to perform echocardiography and electrocardiography on awake mice. This method can be used for primary screening of the murine cardiovascular system in large-scale analysis. We provide insights into the physiological divergence of C57BL/6N, C57BL/6J, C3HeB/FeJ and 129P2/OlaHsd mouse hearts and define the expected normal values. Our report highlights that compared to the other three strains tested C57BL/6N hearts reveal features of heart failure such as hypertrophy and reduced contractile function. We found several features of the mouse ECG to be under genetic control and obtained several strain-specific differences in cardiac structure and function. |
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| DOI: | doi:10.1007/s00360-014-0830-3 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00360-014-0830-3 |
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| | Volltext: https://link.springer.com/article/10.1007%2Fs00360-014-0830-3 |
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| | DOI: https://doi.org/10.1007/s00360-014-0830-3 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1728944147 |
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| Verknüpfungen: | → Zeitschrift |
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High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains / Moreth, Kristin [VerfasserIn]; 1 May 2014 (Online-Ressource)
