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| Verfasst von: | Ertych, Norman [VerfasserIn]  |
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| | Stolz, Ailine [VerfasserIn] |
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| | Stenzinger, Albrecht [VerfasserIn] |
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| | Weichert, Wilko [VerfasserIn] |
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| | Kaulfuß, Silke [VerfasserIn] |
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| | Burfeind, Peter [VerfasserIn] |
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| | Aigner, Achim [VerfasserIn] |
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| | Wordeman, Linda [VerfasserIn] |
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| | Bastians, Holger [VerfasserIn] |
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| Titel: | Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells |
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| Verf.angabe: | Norman Ertych, Ailine Stolz, Albrecht Stenzinger, Wilko Weichert, Silke Kaulfuß, Peter Burfeind, Achim Aigner, Linda Wordeman and Holger Bastians |
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| E-Jahr: | 2014 |
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| Jahr: | 29 June 2014 |
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| Umfang: | 26 S. |
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| Fussnoten: | Gesehen am 07.09.2020 |
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| Titel Quelle: | Enthalten in: Nature cell biology |
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| Ort Quelle: | New York, NY : Nature America, 1999 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 16(2014), 8, Seite 779-791 |
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| ISSN Quelle: | 1476-4679 |
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| Abstract: | Chromosomal instability (CIN) is defined as the perpetual missegregation of whole chromosomes during mitosis and represents a hallmark of human cancer. However, the mechanisms influencing CIN and its consequences on tumour growth are largely unknown. We identified an increase in microtubule plus-end assembly rates as a mechanism influencing CIN in colorectal cancer cells. This phenotype is induced by overexpression of the oncogene AURKA or by loss of the tumour suppressor gene CHK2, a genetic constitution found in 73% of human colorectal cancers. Increased microtubule assembly rates are associated with transient abnormalities in mitotic spindle geometry promoting the generation of lagging chromosomes and influencing CIN. Reconstitution of proper microtubule assembly rates by chemical or genetic means suppresses CIN and thereby, unexpectedly, accelerates tumour growth in vitro and in vivo. Thus, we identify a fundamental mechanism influencing CIN in cancer cells and reveal its adverse consequence on tumour growth. |
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| DOI: | doi:10.1038/ncb2994 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/ncb2994 |
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| | Volltext: https://www.nature.com/articles/ncb2994 |
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| | DOI: https://doi.org/10.1038/ncb2994 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1728948118 |
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| Verknüpfungen: | → Zeitschrift |
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Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells / Ertych, Norman [VerfasserIn]; 29 June 2014 (Online-Ressource)
