| |  Online-Ressource |
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| Verfasst von: | Merz, Maximilian [VerfasserIn]  |
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| | Hielscher, Thomas [VerfasserIn] |
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| | Wagner-Gund, Barbara [VerfasserIn] |
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| | Sauer, Sandra [VerfasserIn] |
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| | Shah, Sofia [VerfasserIn] |
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| | Raab, Marc-Steffen [VerfasserIn] |
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| | Jauch, Anna [VerfasserIn] |
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| | Neben, Kai [VerfasserIn] |
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| | Hose, Dirk [VerfasserIn] |
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| | Egerer, Gerlinde [VerfasserIn] |
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| | Weber, Marc-André [VerfasserIn] |
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| | Delorme, Stefan [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Hillengaß, Jens [VerfasserIn] |
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| Titel: | Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma |
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| Verf.angabe: | M. Merz, T. Hielscher, B. Wagner, S. Sauer, S. Shah, M. S. Raab, A. Jauch, K. Neben, D. Hose, G. Egerer, M.-A. Weber, S. Delorme, H. Goldschmidt, J. Hillengass |
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| E-Jahr: | 2014 |
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| Jahr: | [2014] |
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| Umfang: | 7 S. |
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| Fussnoten: | Advance online publication: 14 March 2014 ; Gesehen am 10.09.2020 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 28(2014), 9, Seite 1902-1908 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | Previous studies demonstrated the relevance of focal lesions (FL) in whole-body magnetic resonance imaging (wb-MRI) at the initial workup of patients with smoldering multiple myeloma (SMM). The aim of this study was to assess the effects of longitudinal wb-MRIs on progression into multiple myeloma (MM). Sixty-three patients with SMM were analyzed who received at least two wb-MRIs for follow-up before progression into MM. Radiological progressive disease (MRI-PD) was defined as detection of new FL or increase in diameter of existing FL and a novel or progressive diffuse infiltration. Radiological stable disease (MRI-SD) was defined by no change compared with the prior MRI. Patients were followed-up every 3-6 months, including a serological and clinical evaluation. One Hundred and eighty-two wb-MRIs were analyzed. MRI-PD occurred in 31 patients (49%), and 25 (40%) patients developed MM. MRI-PD was highly significantly associated with progression into MM, regardless of findings at the initial MRI. In multivariate analysis, MRI-PD remained a risk factor, independent of relevant baseline parameters like serum monoclonal protein or ⩾95% aberrant plasma cells in the bone marrow. Patients with MRI-SD had no higher risk of progression, even when FL were present at the initial MRI. Therefore, MRI is suitable for the follow-up of patients with SMM. |
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| DOI: | doi:10.1038/leu.2014.75 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/leu.2014.75 |
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| | Volltext: https://www.nature.com/articles/leu201475 |
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| | DOI: https://doi.org/10.1038/leu.2014.75 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1729826148 |
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| Verknüpfungen: | → Zeitschrift |
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Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma / Merz, Maximilian [VerfasserIn]; [2014] (Online-Ressource)
