| |  Online-Ressource |
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| Verfasst von: | Kubera, Katharina Maria [VerfasserIn]  |
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| | Wolf, Nadine D. [VerfasserIn] |
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| | Rashidi, Mahmoud [VerfasserIn] |
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| | Hirjak, Dusan [VerfasserIn] |
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| | Northoff, Georg [VerfasserIn] |
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| | Schmitgen, Mike [VerfasserIn] |
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| | Romanov, Dmitry [VerfasserIn] |
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| | Sambataro, Fabio [VerfasserIn] |
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| | Frasch, Karel [VerfasserIn] |
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| | Wolf, Robert Christian [VerfasserIn] |
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| Titel: | Functional decoupling of language and self-reference networks in patients with persistent auditory verbal hallucinations |
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| Verf.angabe: | Katharina M. Kubera, Nadine D. Wolf, Mahmoud Rashidi, Dusan Hirjak, Georg Northoff, Mike M. Schmitgen, Dmitry Romanov, Fabio Sambataro, Karel Frasch, Robert Christian Wolf |
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| Jahr: | 2020 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 10.09.2020 |
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| Titel Quelle: | Enthalten in: Neuropsychobiology |
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| Ort Quelle: | Basel : Karger, 1975 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 79(2020), 4/5, Seite 345-351 |
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| ISSN Quelle: | 1423-0224 |
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| Abstract: | Background:Accumulating neuroimaging evidence suggests that abnormal intrinsic neural activity could underlie auditory verbal hallucinations (AVH) in patients with schizophrenia. However, little is known about the functional interplay between distinct intrinsic neural networks and their association with AVH.Methods:We investigated functional network connectivity (FNC) of distinct resting-state networks as well as the relationship between FNC strength and AVH symptom severity. Resting-state functional MRI data at 3 T were obtained for 14 healthy controls and 10 patients with schizophrenia presenting with persistent AVH. The data were analyzed using a spatial group independent component analysis, followed by constrained maximal lag correlations to determine FNC within and between groups.Results:Four components of interest, comprising language, attention, executive control networks, as well as the default-mode network (DMN), were selected for subsequent FNC analyses. Patients with persistent AVH showed lower FNC between the language network and the DMN (p< 0.05, corrected for false discovery rate). FNC strength, however, was not significantly related to symptom severity, as measured by the Psychotic Symptom Rating Scale.Conclusion:These findings suggest that disrupted FNC between a speech-related system and a network subserving self-referential processing is associated with AVH. The data are consistent with a model of disrupted self-attribution of speech generation and perception. |
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| DOI: | doi:10.1159/000507630 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000507630 |
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| | DOI: https://doi.org/10.1159/000507630 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Auditory verbal hallucinations |
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| | brain |
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| | connectivity |
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| | Functional connectivity |
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| | Functional MRI |
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| | Functional network connectivity |
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| | Independent component analysis |
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| | metaanalysis |
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| | resting-state networks |
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| | schizophrenia |
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| K10plus-PPN: | 1729856985 |
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| Verknüpfungen: | → Zeitschrift |
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Functional decoupling of language and self-reference networks in patients with persistent auditory verbal hallucinations / Kubera, Katharina Maria [VerfasserIn]; 2020 (Online-Ressource)
