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Verfasst von:Clatworthy, Menna R. [VerfasserIn]   i
 Matthews, Rebeccah J. [VerfasserIn]   i
 Doehler, Bernd [VerfasserIn]   i
 Willcocks, Lisa C. [VerfasserIn]   i
 Opelz, Gerhard [VerfasserIn]   i
 Smith, Kenneth G. C. [VerfasserIn]   i
Titel:Defunctioning polymorphism in the immunoglobulin G inhibitory receptor (FcγRIIB-T/T232) does not impact on kidney transplant or recipient survival
Verf.angabe:Menna R. Clatworthy, Rebeccah J. Matthews, Bernd Doehler, Lisa C. Willcocks, Gerhard Opelz, and Kenneth G.C. Smith
Jahr:2014
Umfang:7 S.
Fussnoten:Gesehen am 11.09.2020
Titel Quelle:Enthalten in: Transplantation
Ort Quelle:Hagerstown, Md. : Lippincott Williams & Wilkins, 1963
Jahr Quelle:2014
Band/Heft Quelle:98(2014), 3, Seite 285-291
ISSN Quelle:1534-6080
Abstract:Background - There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells. Most FcγRs are activating and controlled by a single inhibitory receptor, FcγRIIB (CD32B), which also regulates some aspects of B-cell activation and antibody production. FcγRIIB-deficient mice develop severe chronic arteriopathy in a murine cardiac allograft model. A single nucleotide polymorphism in human FcγRIIB (rs1050501) results in profound receptor dysfunction and is associated with systemic lupus erythematosus. The frequency of this FcγRIIB-I/T232 polymorphism also shows significant racial variation. - Methods - In the present study, we sought to determine whether the FcγRIIB-I/T232 single nucleotide polymorphism rs1050501 affected susceptibility to renal allograft rejection or loss and transplant recipient survival. FcγRIIB-I/T232 genotype was determined in 2,851 Caucasian and 570 Afro-Caribbean renal transplant recipients, and in 236 transplant recipients with a primary diagnosis of systemic lupus erythematosus, all of whom were enrolled into the Collaborative Transplant Study. - Results - We found no significant difference in pretransplant panel reactive antibodies, acute rejection at 1-year nor in 10-year transplant or patient survival in individuals with differing FcγRIIB-I/T232 genotype. - Conclusion - This negative result is surprising, given the importance of this receptor in modulating antibody effector function.
DOI:doi:10.1097/TP.0000000000000287
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/TP.0000000000000287
 Volltext: https://journals.lww.com/transplantjournal/Fulltext/2014/08150/Defunctioning_Polymorphism_in_the_Immunoglobulin_G.11.asp ...
 DOI: https://doi.org/10.1097/TP.0000000000000287
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1730481272
Verknüpfungen:→ Zeitschrift

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