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Status: Bibliographieeintrag

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Verfasst von:Elsayad, Khaled [VerfasserIn]   i
 König, Laila [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Herfarth, Klaus [VerfasserIn]   i
Titel:Maximizing the clinical benefit of radiotherapy in solitary plasmacytoma
Titelzusatz:an international multicenter analysis
Verf.angabe:Khaled Elsayad, Michael Oertel, Laila König, Sebastian Hüske, Emmanuelle Le Ray, Mohamed A. M. Meheissen, Amr Abdelaziz Elsaid, Essam Elfaham, Jürgen Debus, Youlia Kirova, Klaus Herfarth and Hans Theodor Eich
E-Jahr:2020
Jahr:13 March 2020
Umfang:12 S.
Fussnoten:Gesehen am 11.09.2020
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2020
Band/Heft Quelle:12(2020,3) Artikel-Nummer 676, 12 Seiten
ISSN Quelle:2072-6694
Abstract:Objective: Although local definitive radiotherapy (RT) is considered the standard of care for solitary plasmacytoma (SP), the optimal RT parameters for SP patients have not been defined. The aim of this retrospective study is to analyze the effectiveness of various RT doses, volumes, and techniques, as well as to define the relevant prognostic factors in SP. Methods: Between 2000 and 2019, 84 patients, including 54 with solitary bone plasmacytoma (SBP) and 30 with extramedullary plasmacytoma (EMP), underwent RT at six institutions. Results: The overall RT median dose was 42 Gy (range, 36.0 - 59.4). The median follow-up period was 46 months. Overall, the local control (LC) rate was 96%, while the complete remission (CR) rate was 46%. The 5-year local relapse-free survival (LRFS), multiple myeloma-free survival (MMFS), progression-free survival (PFS), and overall survival (OS) rates were 89%, 71%, 55%, and 93%, respectively. Using an RT dose above 40 Gy was associated with a higher complete remission (CR) rate and a lower rate of local relapse. Modern irradiation techniques were associated with a trend toward a higher LC rate (98% vs. 87% for conventional, p = 0.09) and a significantly lower local relapse rate (6% vs. 25% for conventional, p = 0.04). However, RT dose escalation and technique did not lead to a significant effect on MMFS, PFS, and OS. Univariate analyses identified several patient characteristics as potentially relevant prognostic factors. In SBP patients, systemic therapy administration was associated significantly with MMFS and PFS rates. Conclusion: Using an RT dose > 40 Gy and modern RT techniques may improve the local control and reduce the rate of relapse, without a significant impact on survival rates. The addition of systemic therapies may improve the MMFS and PFS rates of SBP patients.
DOI:doi:10.3390/cancers12030676
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/cancers12030676
 Volltext: https://www.mdpi.com/2072-6694/12/3/676
 DOI: https://doi.org/10.3390/cancers12030676
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:combined radiotherapy
 extramedullary
 IMRT
 solitary bone plasmacytoma
K10plus-PPN:1730526438
Verknüpfungen:→ Zeitschrift

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