| |  Online-Ressource |
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| Verfasst von: | Stanifer, Megan [VerfasserIn]  |
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| | Kee, Carmon [VerfasserIn] |
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| | Cortese, Mirko [VerfasserIn] |
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| | Metz Zumarán, Camila [VerfasserIn] |
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| | Triana, Sergio [VerfasserIn] |
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| | Mukenhirn, Markus [VerfasserIn] |
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| | Kräusslich, Hans-Georg [VerfasserIn] |
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| | Alexandrov, Theodore [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | Boulant, Steeve [VerfasserIn] |
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| Titel: | Critical role of type III interferon in controlling SARS-CoV-2 infection in human intestinal epithelial cells |
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| Verf.angabe: | Megan L. Stanifer, Carmon Kee, Mirko Cortese, Camila Metz Zumaran, Sergio Triana, Markus Mukenhirn, Hans-Georg Kraeusslich, Theodore Alexandrov, Ralf Bartenschlager, and Steeve Boulant |
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| E-Jahr: | 2020 |
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| Jahr: | 19 June 2020 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 14.09.2020 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 32(2020,1) Artikel-Nummer 107863, 15 Seiten |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is an unprecedented worldwide health problem that requires concerted and global approaches to stop the coronavirus 2019 (COVID-19) pandemic. Although SARS-CoV-2 primarily targets lung epithelium cells, there is growing evidence that the intestinal epithelium is also infected. Here, using both colon-derived cell lines and primary non-transformed colon organoids, we engage in the first comprehensive analysis of the SARS-CoV-2 life cycle in human intestinal epithelial cells (hIECs). Our results demonstrate that hIECs fully support SARS-CoV-2 infection, replication, and production of infectious de novo virus particles. We found that viral infection elicits an extremely robust intrinsic immune response where interferon-mediated responses are efficient at controlling SARS-CoV-2 replication and de novo virus production. Taken together, our data demonstrate that hIECs are a productive site of SARS-CoV-2 replication and suggest that the enteric phase of SARS-CoV-2 may participate in the pathologies observed in COVID-19 patients by contributing to increasing patient viremia and fueling an exacerbated cytokine response. |
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| DOI: | doi:10.1016/j.celrep.2020.107863 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2020.107863 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2211124720308445 |
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| | DOI: https://doi.org/10.1016/j.celrep.2020.107863 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | human intestinal epithelial cells |
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| | IFN |
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| | interferon |
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| | interferon lambda |
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| | interferon stimulted genes |
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| | intrinsic immunity |
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| | ISGs |
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| | organoids |
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| | SARS-CoV-2 |
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| K10plus-PPN: | 1731779933 |
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| Verknüpfungen: | → Zeitschrift |
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Critical role of type III interferon in controlling SARS-CoV-2 infection in human intestinal epithelial cells / Stanifer, Megan [VerfasserIn]; 19 June 2020 (Online-Ressource)
