| |  Online-Ressource |
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| Verfasst von: | Graßmann, Sophie [VerfasserIn]  |
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| | Pivovarova-Ramich, Olga [VerfasserIn] |
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| | Henze, Andrea [VerfasserIn] |
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| | Raila, Jens [VerfasserIn] |
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| | Ampem Amoako, Yaw [VerfasserIn] |
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| | King Nyamekye, Richard [VerfasserIn] |
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| | Bedu-Addo, George [VerfasserIn] |
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| | Mockenhaupt, Frank P. [VerfasserIn] |
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| | Schulze, Matthias B. [VerfasserIn] |
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| | Danquah, Ina [VerfasserIn] |
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| Titel: | SNP rs6564851 in the BCO1 gene is associated with varying provitamin A plasma concentrations but not with retinol concentrations among adolescents from rural Ghana |
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| Verf.angabe: | Sophie Graßmann, Olga Pivovarova-Ramich, Andrea Henze, Jens Raila, Yaw Ampem Amoako, Richard King Nyamekye, George Bedu-Addo, Frank P. Mockenhaupt, Matthias B. Schulze and Ina Danquah |
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| E-Jahr: | 2020 |
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| Jahr: | 16 June 2020 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 14.09.2020 |
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| Titel Quelle: | Enthalten in: Nutrients |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 12(2020,6) Artikel-Nummer 1786, 14 Seiten |
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| ISSN Quelle: | 2072-6643 |
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| Abstract: | In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A carotenoids is essential. Previously, adolescents in rural Ghana have shown high total plasma carotenoid concentrations, while 36% had a vitamin A deficiency (defined as plasma retinol < 0.7 µmol/L). Hence, the aim of this cross-sectional study was to identify the relationships between variants in the β-carotene 15,15’-oxygenase (BCO1) gene and plasma carotenoid concentrations among 189 15-year-old girls and boys in rural Ghana. BCO1 rs6564851, rs7500996, rs10048138 and PKD1L2 rs6420424, and rs8044334 were typed, and carotenoid concentrations were compared among the different genotypes. G allele carriers of rs6564851 (53%) showed higher plasma carotenoid concentrations than T allele carriers (median (interquartile range): 3.07 (2.17-4.02) vs. 2.59 (2.21-3.50) µmol/L, p-value = 0.0424). This was not explained by differences in socio-demographic or dietary factors. In contrast, no differences in plasma retinol concentrations were observed between these genotypes. Pending verification in independent populations, the low conversion efficiency of provitamin A carotenoids among rs6564851 G allele carriers may undermine existing fortification and supplementation programs to improve the vitamin A status in sub-Saharan Africa. |
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| DOI: | doi:10.3390/nu12061786 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/nu12061786 |
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| | Volltext: https://www.mdpi.com/2072-6643/12/6/1786 |
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| | DOI: https://doi.org/10.3390/nu12061786 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | BCO1 |
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| | carotenoids |
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| | Ghana |
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| | single nucleotide polymorphism |
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| | vitamin A deficiency |
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| K10plus-PPN: | 1731786646 |
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| Verknüpfungen: | → Zeitschrift |
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SNP rs6564851 in the BCO1 gene is associated with varying provitamin A plasma concentrations but not with retinol concentrations among adolescents from rural Ghana / Graßmann, Sophie [VerfasserIn]; 16 June 2020 (Online-Ressource)
