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Status: Bibliographieeintrag

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Verfasst von:Wallace, David R. [VerfasserIn]   i
 Taalab, Yasmeen M. [VerfasserIn]   i
 Heinze, Sarah [VerfasserIn]   i
Titel:Toxic-metal-induced alteration in miRNA expression profile as a proposed mechanism for disease development
Verf.angabe:David R. Wallace, Yasmeen M. Taalab, Sarah Heinze, Blanka Tariba Lovaković, Alica Pizent, Elisavet Renieri, Aristidis Tsatsakis, Ammad Ahmad Farooqi, Dragana Javorac, Milena Andjelkovic, Zorica Bulat, Biljana Antonijević and Aleksandra Buha Djordjevic
E-Jahr:2020
Jahr:7 April 2020
Umfang:22 S.
Fussnoten:Gesehen am 14.09.2020
Titel Quelle:Enthalten in: Cells
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2020
Band/Heft Quelle:9(2020,4) Artikel-Nummer 901, 22 Seiten
ISSN Quelle:2073-4409
Abstract:Toxic metals are extensively found in the environment, households, and workplaces and contaminate food and drinking water. The crosstalk between environmental exposure to toxic metals and human diseases has been frequently described. The toxic mechanism of action was classically viewed as the ability to dysregulate the redox status, production of inflammatory mediators and alteration of mitochondrial function. Recently, growing evidence showed that heavy metals might exert their toxicity through microRNAs (miRNA)—short, single-stranded, noncoding molecules that function as positive/negative regulators of gene expression. Aberrant alteration of the endogenous miRNA has been directly implicated in various pathophysiological conditions and signaling pathways, consequently leading to different types of cancer and human diseases. Additionally, the gene-regulatory capacity of miRNAs is particularly valuable in the brain—a complex organ with neurons demonstrating a significant ability to adapt following environmental stimuli. Accordingly, dysregulated miRNAs identified in patients suffering from neurological diseases might serve as biomarkers for the earlier diagnosis and monitoring of disease progression. This review will greatly emphasize the effect of the toxic metals on human miRNA activities and how this contributes to progression of diseases such as cancer and neurodegenerative disorders (NDDs).
DOI:doi:10.3390/cells9040901
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/cells9040901
 Volltext: https://www.mdpi.com/2073-4409/9/4/901
 DOI: https://doi.org/10.3390/cells9040901
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:arsenic
 cadmium
 cancer
 epigenetic modification
 gene expression
 lead
 manganese
 mercury
 miRNA
 neurodegenerative diseases (NDDs)
K10plus-PPN:1731818963
Verknüpfungen:→ Zeitschrift

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