Comparative analysis of the discriminatory performance of different well-known risk assessment scores for extended hepatectomy

• Verfasst von: Ghamarnejad, Omid [VerfasserIn]
• Verfasst von: Khajeh, Elias [VerfasserIn]
• Verfasst von: Rezaei, Nahid [VerfasserIn]
• Verfasst von: Afshari, Khashayar [VerfasserIn]
• Verfasst von: Adelian, Ali [VerfasserIn]
• Verfasst von: Nikdad, Mohammadsadegh [VerfasserIn]
• Verfasst von: Hoffmann, Katrin [VerfasserIn]
• Verfasst von: Mehrabi, Arianeb [VerfasserIn]
• Titel: Comparative analysis of the discriminatory performance of different well-known risk assessment scores for extended hepatectomy
• Verf.angabe: Omid Ghamarnejad, Elias Khajeh, Nahid Rezaei, Khashayar Afshari, Ali Adelian, Mohammadsadegh Nikdad, Katrin Hoffmann & Arianeb Mehrabi
• E-Jahr: 2020
• Jahr: 22 January 2020
• Umfang: 9 S.
• Fussnoten: Gesehen am 15.09.2020
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2020
• Band/Heft Quelle: 10(2020) Artikel-Nummer 930, 9 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-020-57748-7
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1732488495

Abstract

The aim of this study was to assess and compare the discriminatory performance of well-known risk assessment scores in predicting mortality risk after extended hepatectomy (EH). A series of 250 patients who underwent EH (≥5 segments resection) were evaluated. Aspartate aminotransferase-to-platelet ratio index (APRI), albumin to bilirubin (ALBI) grade, predictive score developed by Breitenstein et al., liver fibrosis (FIB-4) index, and Heidelberg reference lines charting were used to compute cut-off values, and the sensitivity and specificity of each risk assessment score for predicting mortality were also calculated. Major morbidity and 90-day mortality after EH increased with increasing risk scores. APRI (86%), ALBI (86%), Heidelberg score (81%), and FIB-4 index (79%) had the highest sensitivity for 90-day mortality. However, only the FIB-4 index and Heidelberg score had an acceptable specificity (70% and 65%, respectively). A two-stage risk assessment strategy (Heidelberg-FIB-4 model) with a sensitivity of 70% and a specificity 86% for 90-day mortality was proposed. There is no single specific risk assessment score for patients who undergo EH. A two-stage screening strategy using Heidelberg score and FIB-4 index was proposed to predict mortality after major liver resection.