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| Verfasst von: | Lutz, Kira [VerfasserIn]  |
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| | Wiestler, Benedikt [VerfasserIn] |
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| | Graf, Markus [VerfasserIn] |
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| | Bäumer, Philipp [VerfasserIn] |
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| | Floca, Ralf [VerfasserIn] |
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| | Schlemmer, Heinz-Peter [VerfasserIn] |
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| | Heiland, Sabine [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Radbruch, Alexander [VerfasserIn] |
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| Titel: | Infiltrative patterns of glioblastoma |
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| Titelzusatz: | identification of tumor progress using apparent diffusion coefficient histograms |
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| Verf.angabe: | Kira Lutz MD, Benedikt Wiestler MD, Markus Graf MSc, Philipp Bäumer MD, Ralf Floca PhD, Heinz-Peter Schlemmer MD, PhD, Sabine Heiland PhD, Wolfgang Wick MD, Martin Bendszus MD, and Alexander Radbruch MD, JD |
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| Jahr: | 2014 |
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| Jahr des Originals: | 2013 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 15.09.2020 ; First published: 30 September 2013 |
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| Titel Quelle: | Enthalten in: Journal of magnetic resonance imaging |
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| Ort Quelle: | New York, NY : Wiley-Liss, 1991 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 39(2014), 5, Seite 1096-1103 |
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| ISSN Quelle: | 1522-2586 |
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| Abstract: | Purpose To investigate whether apparent diffusion coefficient (ADC) histogram analysis can differentiate between patients presenting T2-progress and patients presenting stable T2-signal in glioblastoma. Materials and Methods Fourteen patients presenting an isolated T2-progress and a matched control group exhibiting stable disease were included. Relative ADC value distribution within tumoral and peritumoral FLAIR hyperintensities were evaluated using ADC-histogram analysis. Severity and frequency of ADC shift between baseline, T2-progress, and subsequent T1-progress were analyzed using the Wilcoxon test. Results The shift of ADC histograms either to higher or to lower values in case of T2-progress was significantly more severe than in the control group (P value 0.05). Furthermore, a significant shift toward lower ADC values (P value 0.02) was detected when comparing ADC histograms of patients with T2-progress and subsequent T1-progress. Conclusion The basis for the observed ADC shift in isolated T2-progress may be time dependent: Initially, formation of peritumoral edema may cause an increase of ADC values that is followed by tumor cells infiltrating the surrounding tissue, causing a subsequent decrease of ADC values. The shift toward lower ADC values in case of subsequent T1-progress confirms this hypothesis and provides further evidence for T2-progress being an intermediate step between stable disease (SD) and T1-progress. J. Magn. Reson. Imaging 2014;39:1096-1103. © 2013 Wiley Periodicals, Inc. |
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| DOI: | doi:10.1002/jmri.24258 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/jmri.24258 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.24258 |
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| | DOI: https://doi.org/10.1002/jmri.24258 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ADC-histogram |
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| | glioblastoma |
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| | RANO-criteria |
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| | T2-progress |
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| K10plus-PPN: | 1732498229 |
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| Verknüpfungen: | → Zeitschrift |
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Infiltrative patterns of glioblastoma / Lutz, Kira [VerfasserIn]; 2014 (Online-Ressource)
