Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

• Verfasst von: Hillier, Ladeana [VerfasserIn]
• Verfasst von: Bork, Peer [VerfasserIn]
• Verfasst von: Letunić, Ivica [VerfasserIn]
• Verfasst von: Mering, Christian von [VerfasserIn]
• Titel: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
• Körperschaft: International Chicken Genome Sequencing Consortium [VerfasserIn]
• Verf.angabe: International Chicken Genome Sequencing Consortium
• E-Jahr: 2004
• Jahr: 9 December 2004
• Umfang: 22 S.
• Fussnoten: International Chicken Genome Sequencing Consortium: Peer Bork, Ivaca Letunic, Christian von Mering [und 172 weitere] ; Gesehen am 16.09.2020
• Titel Quelle: Enthalten in: Nature <London>
• Ort Quelle: London [u.a.] : Nature Publ. Group, 1869
• Jahr Quelle: 2004
• Band/Heft Quelle: 432(2004), 7018, Seite 695-716
• ISSN Quelle: 1476-4687
• DOI: doi:10.1038/nature03154
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1733107304

Abstract

We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome—composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes—provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.