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| Verfasst von: | Turvey, Stuart E. [VerfasserIn]  |
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| | Durandy, Anne [VerfasserIn] |
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| | Fischer, Alain [VerfasserIn] |
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| | Fung, Shan-Yu [VerfasserIn] |
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| | Geha, Raif S. [VerfasserIn] |
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| | Gewies, Andreas [VerfasserIn] |
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| | Giese, Thomas [VerfasserIn] |
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| | Greil, Johann [VerfasserIn] |
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| | Keller, Bärbel [VerfasserIn] |
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| | McKinnon, Margaret L. [VerfasserIn] |
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| | Neven, Bénédicte [VerfasserIn] |
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| | Rozmus, Jacob [VerfasserIn] |
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| | Ruland, Jürgen [VerfasserIn] |
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| | Snow, Andrew L. [VerfasserIn] |
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| | Stepensky, Polina [VerfasserIn] |
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| | Warnatz, Klaus [VerfasserIn] |
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| Titel: | The CARD11-BCL10-MALT1 (CBM) signalosome complex |
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| Titelzusatz: | Stepping into the limelight of human primary immunodeficiency |
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| Verf.angabe: | Stuart E. Turvey, BBS, DPhil, FRCPC, Anne Durandy, MD, PhD, Alain Fischer, MD, PhD, Shan-Yu Fung, PhD, Raif S. Geha, MD, Andreas Gewies, PhD, Thomas Giese, MD, Johann Greil, MD, Bärbel Keller, MSc, Margaret L. McKinnon, MD, Bénédicte Neven, MD, Jacob Rozmus, MD, Jürgen Ruland, MD, Andrew L. Snow, PhD, Polina Stepensky, MD, and Klaus Warnatz, MD |
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| E-Jahr: | 2014 |
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| Jahr: | 31 July 2014 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 16.09.2020 |
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| Titel Quelle: | Enthalten in: The journal of allergy and clinical immunology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1971 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 134(2014), 2, Seite 276-284 |
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| ISSN Quelle: | 1097-6825 |
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| Abstract: | Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be lifesaving for the affected patients and also provide a unique opportunity to study the effect of specific genes on human immune function. In the past 18 months, a number of independent groups have begun to define novel PIDs caused by defects in the caspase recruitment domain family, member 11 (CARD11)-B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10)-mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1 [CBM]) signalosome complex. The CBM complex forms an essential molecular link between the triggering of cell-surface antigen receptors and nuclear factor κB activation. Germline mutations affecting the CBM complex are now recognized as the cause of novel combined immunodeficiency phenotypes, which all share abnormal nuclear factor κB activation and dysregulated B-cell development as defining features. For this “Current perspectives” article, we have engaged experts in both basic biology and clinical immunology to capture the worldwide experience in recognizing and managing patients with PIDs caused by CBM complex mutations. |
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| DOI: | doi:10.1016/j.jaci.2014.06.015 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jaci.2014.06.015 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0091674914008653 |
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| | DOI: https://doi.org/10.1016/j.jaci.2014.06.015 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CARMA1 |
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| | combined immunodeficiency |
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| | congenital B-cell lymphocytosis |
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| | next-generation sequencing |
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| | nuclear factor κB |
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| | paracaspase |
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| | primary immunodeficiency diseases |
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| | signalosome complex |
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| K10plus-PPN: | 1733112340 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ CARD11-BCL10-MALT1 (CBM) signalosome complex / Turvey, Stuart E. [VerfasserIn]; 31 July 2014 (Online-Ressource)
