| |  Online-Ressource |
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| Verfasst von: | Benesch, Martin [VerfasserIn]  |
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| | Bartelheim, Kerstin [VerfasserIn] |
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| | Fleischhack, G. [VerfasserIn] |
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| | Gruhn, Bernd [VerfasserIn] |
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| | Schlegel, Paul-Gerhardt [VerfasserIn] |
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| | Witt, Olaf [VerfasserIn] |
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| | Stachel, Klaus Daniel [VerfasserIn] |
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| | Hauch, Holger [VerfasserIn] |
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| | Urban, Christian [VerfasserIn] |
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| | Quehenberger, F. [VerfasserIn] |
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| | Massimino, M. [VerfasserIn] |
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| | Pietsch, T. [VerfasserIn] |
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| | Hasselblatt, Martin [VerfasserIn] |
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| | Giangaspero, F. [VerfasserIn] |
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| | Kordes, Uwe [VerfasserIn] |
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| | Schneppenheim, Reinhard [VerfasserIn] |
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| | Hauser, Peter [VerfasserIn] |
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| | Klingebiel, Thomas [VerfasserIn] |
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| | Frühwald, Michael [VerfasserIn] |
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| Titel: | High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT) |
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| Titelzusatz: | a report from the European Rhabdoid Registry (EU-RHAB) |
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| Verf.angabe: | M. Benesch, K. Bartelheim, G. Fleischhack, B. Gruhn, P.G. Schlegel, O. Witt, K.D. Stachel, H. Hauch, C. Urban, F. Quehenberger, M. Massimino, T. Pietsch, M. Hasselblatt, F. Giangaspero, U. Kordes, R. Schneppenheim, P. Hauser, T. Klingebiel and M.C. Frühwald |
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| E-Jahr: | 2014 |
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| Jahr: | 13 January 2014 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 16.09.2020 |
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| Titel Quelle: | Enthalten in: Bone marrow transplantation |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 49(2014), 3, Seite 370-375 |
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| ISSN Quelle: | 1476-5365 |
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| Abstract: | A retrospective analysis of data from the European Rhabdoid Registry (EU-RHAB) was performed to describe the outcome of children with atypical teratoid/rhabdoid tumors (AT/RT) who underwent high-dose chemotherapy (HDCT) with auto-SCT. Nineteen patients (male, n=15; median age at diagnosis 21 months) were identified. Nine patients presented with metastatic disease at diagnosis. A partial or subtotal resection was achieved in 11, a total resection in five and a biopsy in three patients. Patients received a median of six chemotherapy cycles prior to HDCT. Additional radiotherapy was performed in 14 patients (first-line, n=9; following progression, n=5). Six patients underwent tandem auto-SCT. Disease status before HDCT was CR in six, PR in eight, stable disease in two and progressive disease (PD) in two patients (data missing, n=1). With a median follow-up of 16 months, 14 patients progressed. Estimated progression-free and OS at 2 years were 29% (±11%) and 50% (±12%), respectively. At last follow-up, eight patients were alive (first CR, n=4; second CR, n=2; PR, n=1; PD, n=1). Eleven patients died of PD. Median time-to-progression was 14 months. Selected patients with AT/RT might benefit from HDCT with radiotherapy. The definitive impact of this treatment modality has to be evaluated prospectively in a randomized trial. |
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| DOI: | doi:10.1038/bmt.2013.208 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/bmt.2013.208 |
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| | Volltext: https://www.nature.com/articles/bmt2013208 |
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| | DOI: https://doi.org/10.1038/bmt.2013.208 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1733114416 |
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| Verknüpfungen: | → Zeitschrift |
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High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT) / Benesch, Martin [VerfasserIn]; 13 January 2014 (Online-Ressource)
