Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Thornton, Timothy A. [VerfasserIn]   i
 Lorenzo Bermejo, Justo [VerfasserIn]   i
Titel:Local and global ancestry inference and applications to genetic association analysis for admixed populations
Verf.angabe:Timothy A. Thornton and Justo Lorenzo Bermejo
E-Jahr:2014
Jahr:[2014]
Umfang:8 S.
Fussnoten:First published: 11 August 2014 ; Gesehen am 16.09.2020
Titel Quelle:Enthalten in: Genetic epidemiology
Ort Quelle:New York, NY : Wiley-Liss, 1984
Jahr Quelle:2014
Band/Heft Quelle:38(2014,S1), Seite S5-S12
ISSN Quelle:1098-2272
Abstract:Genetic association studies in recently admixed populations offer exciting opportunities to identify novel variants underlying phenotypic diversity. At the same time, genetic heterogeneity resulting from population admixture has to be accounted for to ensure validity of association tests. The whole-genome sequence data and the genome-wide single-nucleotide polymorphism chip data for Mexican American individuals provided by Genetic Analysis Workshop 18 (GAW18) presents a unique opportunity to evaluate and compare methods for the statistical analysis of admixed genetic data. We summarize here the five contributions from the GAW18 working group on admixture mapping and adjusting for admixture. Although group members considered a variety of research topics, the general theme was inference and consideration of ancestry admixture in genetic analyses. The topics considered can be grouped into three categories: (1) global and local ancestry inference and estimation, (2) association and admixture mapping, and (3) genotype imputation in admixed samples. We describe the approaches that were used and the most relevant findings from each contribution. We also provide insight into the strengths and limitations of the state-of-the-art methods considered for genetic analyses in admixed populations.
DOI:doi:10.1002/gepi.21819
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/gepi.21819
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/gepi.21819
 DOI: https://doi.org/10.1002/gepi.21819
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:admixture
 association
 genotype imputation
 GWAS
 local ancestry
K10plus-PPN:1733154175
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68638083   QR-Code
zum Seitenanfang