| |  Online-Ressource |
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| Verfasst von: | Sindi, Hebah A. [VerfasserIn]  |
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| | Russomanno, Giusy [VerfasserIn] |
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| | Satta, Sandro [VerfasserIn] |
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| | Abdul-Salam, Vahitha B. [VerfasserIn] |
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| | Jo, Kyeong Beom [VerfasserIn] |
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| | Qazi-Chaudhry, Basma [VerfasserIn] |
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| | Ainscough, Alexander J. [VerfasserIn] |
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| | Szulcek, Robert [VerfasserIn] |
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| | Jan Bogaard, Harm [VerfasserIn] |
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| | Morgan, Claire C. [VerfasserIn] |
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| | Pullamsetti, Soni S. [VerfasserIn] |
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| | Alzaydi, Mai M. [VerfasserIn] |
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| | Rhodes, Christopher J. [VerfasserIn] |
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| | Piva, Roberto [VerfasserIn] |
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| | Eichstaedt, Christina [VerfasserIn] |
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| | Grünig, Ekkehard [VerfasserIn] |
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| | Wilkins, Martin R. [VerfasserIn] |
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| | Wojciak-Stothard, Beata [VerfasserIn] |
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| Titel: | Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension |
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| Verf.angabe: | Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins & Beata Wojciak-Stothard |
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| E-Jahr: | 2020 |
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| Jahr: | 04 March 2020 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 17.09.2020 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 11(2020) Artikel-Nummer 1185, 17 Seiten |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH. Here, we show that KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324-5p act together to attenuate pulmonary vascular remodelling and that their actions are mediated by Notch4 and ETS1 and other key regulators of vascular homoeostasis. Expressions of KLF2, miR-181a-5p and miR-324-5p are reduced, while levels of their target genes are elevated in pre-clinical PAH, idiopathic PAH and heritable PAH with missense p.H288Y KLF2 mutation. Therapeutic supplementation of miR-181a-5p and miR-324-5p reduces proliferative and angiogenic responses in patient-derived cells and attenuates disease progression in PAH mice. This study shows that reduced KLF2 signalling is a common feature of human PAH and highlights the potential therapeutic role of KLF2-regulated exosomal miRNAs in PAH and other diseases associated with vascular remodelling. |
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| DOI: | doi:10.1038/s41467-020-14966-x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41467-020-14966-x |
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| | Volltext: https://www.nature.com/articles/s41467-020-14966-x |
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| | DOI: https://doi.org/10.1038/s41467-020-14966-x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1733203222 |
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| Verknüpfungen: | → Zeitschrift |
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension / Sindi, Hebah A. [VerfasserIn]; 04 March 2020 (Online-Ressource)
