| Online-Ressource |
Verfasst von: | Sindi, Hebah A. [VerfasserIn]  |
| Russomanno, Giusy [VerfasserIn]  |
| Satta, Sandro [VerfasserIn]  |
| Abdul-Salam, Vahitha B. [VerfasserIn]  |
| Jo, Kyeong Beom [VerfasserIn]  |
| Qazi-Chaudhry, Basma [VerfasserIn]  |
| Ainscough, Alexander J. [VerfasserIn]  |
| Szulcek, Robert [VerfasserIn]  |
| Jan Bogaard, Harm [VerfasserIn]  |
| Morgan, Claire C. [VerfasserIn]  |
| Pullamsetti, Soni S. [VerfasserIn]  |
| Alzaydi, Mai M. [VerfasserIn]  |
| Rhodes, Christopher J. [VerfasserIn]  |
| Piva, Roberto [VerfasserIn]  |
| Eichstaedt, Christina [VerfasserIn]  |
| Grünig, Ekkehard [VerfasserIn]  |
| Wilkins, Martin R. [VerfasserIn]  |
| Wojciak-Stothard, Beata [VerfasserIn]  |
Titel: | Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension |
Verf.angabe: | Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins & Beata Wojciak-Stothard |
E-Jahr: | 2020 |
Jahr: | 04 March 2020 |
Umfang: | 17 S. |
Fussnoten: | Gesehen am 17.09.2020 |
Titel Quelle: | Enthalten in: Nature Communications |
Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 11(2020) Artikel-Nummer 1185, 17 Seiten |
ISSN Quelle: | 2041-1723 |
Abstract: | Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH. Here, we show that KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324-5p act together to attenuate pulmonary vascular remodelling and that their actions are mediated by Notch4 and ETS1 and other key regulators of vascular homoeostasis. Expressions of KLF2, miR-181a-5p and miR-324-5p are reduced, while levels of their target genes are elevated in pre-clinical PAH, idiopathic PAH and heritable PAH with missense p.H288Y KLF2 mutation. Therapeutic supplementation of miR-181a-5p and miR-324-5p reduces proliferative and angiogenic responses in patient-derived cells and attenuates disease progression in PAH mice. This study shows that reduced KLF2 signalling is a common feature of human PAH and highlights the potential therapeutic role of KLF2-regulated exosomal miRNAs in PAH and other diseases associated with vascular remodelling. |
DOI: | doi:10.1038/s41467-020-14966-x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41467-020-14966-x |
| Volltext: https://www.nature.com/articles/s41467-020-14966-x |
| DOI: https://doi.org/10.1038/s41467-020-14966-x |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1733203222 |
Verknüpfungen: | → Zeitschrift |
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension / Sindi, Hebah A. [VerfasserIn]; 04 March 2020 (Online-Ressource)