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Verfasst von:Leskelä, Jaakko [VerfasserIn]   i
 Safer, Anton [VerfasserIn]   i
 Becher, Heiko [VerfasserIn]   i
 Grau, Armin J. [VerfasserIn]   i
 Palm, Frederick [VerfasserIn]   i
Titel:Serum lipopolysaccharide neutralizing capacity in ischemic stroke
Verf.angabe:Jaakko Leskelä, Milla Pietiäinen, Anton Safer, Markku Lehto, Jari Metso, Ernst Malle, Florian Buggle, Heiko Becher, Jouko Sundvall, Armin J. Grau, Pirkko J. Pussinen, Frederick Palm
E-Jahr:2020
Jahr:February 21, 2020
Umfang:17 S.
Fussnoten:Gesehen am 18.09.2020
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2020
Band/Heft Quelle:15(2020,2) Artikel-Nummer e0228806, 17 Seiten
ISSN Quelle:1932-6203
Abstract:Introduction: Periodontitis is associated with increased serum lipopolysaccharide (LPS) activity, which may be one mechanism linking periodontitis with the risk of cardiovascular diseases. As LPS-carrying proteins including lipoproteins modify LPS-activity, we investigated the determinants of serum LPS-neutralizing capacity (LPS-NC) in ischemic stroke. The association of LPS-NC and Aggregatibacter actinomycetemcomitans, a major microbial biomarker in periodontitis, was also investigated. Materials and methods: The assay to measure LPS-NC was set up by spiking serum samples with E. coli LPS. The LPS-NC, LPS-binding protein (LBP), soluble CD14 (sCD14), lipoprotein profiles, apo(lipoprotein) A-I, apoB, and phospholipid transfer protein (PLTP) activity, were determined in 98 ischemic stroke patients and 100 age- and sex-matched controls. Serum and saliva immune response to A. actinomycetemcomitans, its concentration in saliva, and serotype-distribution were examined. Results: LPS-NC values ranged between 51-83% in the whole population. Although several of the LPS-NC determinants differed significantly between cases and controls (PLTP, sCD14, apoA-I, HDL-cholesterol), the levels did not (p = 0.056). The main determinants of LPS-NC were i) triglycerides (β = -0.68, p<0.001), and ii) HDL cholesterol (0.260, <0.001), LDL cholesterol (-0.265, <0.001), PLTP (-0.196, 0.011), and IgG against A. actinomycetemcomitans (0.174, 0.011). Saliva A. actinomycetemcomitans concentration was higher [log mean (95% CI), 4.39 (2.35-8.19) vs. 10.7 (5.45-21) genomes/ml, p = 0.023) and serotype D more frequent (4 vs. 0%, p = 0.043) in cases than controls. Serotypeablity or serotypes did not, however, relate to the LPS-NC. Conclusion: Serum LPS-NC comprised low PLTP-activity, triglyceride and LDL cholesterol concentrations, as well as high HDL cholesterol and IgG against A. actinomycetemcomitans. The present findings let us to conclude that LPS-NC did not associate with stroke.
DOI:doi:10.1371/journal.pone.0228806
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1371/journal.pone.0228806
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228806
 DOI: https://doi.org/10.1371/journal.pone.0228806
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cholesterol
 Endotoxemia
 Endotoxins
 Enzyme-linked immunoassays
 Ischemic stroke
 Lipids
 Lipoproteins
 Saliva
K10plus-PPN:1733328068
Verknüpfungen:→ Zeitschrift

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