GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ

• Verfasst von: Dikmen, Hasan Onur [VerfasserIn]
• Verfasst von: Hemmerich, Marc [VerfasserIn]
• Verfasst von: Lewen, Andrea [VerfasserIn]
• Verfasst von: Hollnagel, Jan-Oliver [VerfasserIn]
• Verfasst von: Chausse de Freitas, Bruno [VerfasserIn]
• Verfasst von: Kann, Oliver [VerfasserIn]
• Titel: GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ
• Verf.angabe: Hasan Onur Dikmen, Marc Hemmerich, Andrea Lewen, Jan-Oliver Hollnagel, Bruno Chausse and Oliver Kann
• E-Jahr: 2020
• Jahr: [2020]
• Umfang: 13 S.
• Illustrationen: Illustrationen
• Fussnoten: Published: 11 August 2020 ; Gesehen am 18.09.2020
• Titel Quelle: Enthalten in: Journal of neuroinflammation
• Ort Quelle: London : BioMed Central, 2004
• Jahr Quelle: 2020
• Band/Heft Quelle: 17(2020) Artikel-Nummer 235, 13 Seiten
• ISSN Quelle: 1742-2094
• DOI: doi:10.1186/s12974-020-01903-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 173333260X
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

The granulocyte-macrophage colony-stimulating factor (GM-CSF) (or CSF-2) is involved in myeloid cell growth and differentiation, and, possibly, a major mediator of inflammation in body tissues. The role of GM-CSF in the activation of microglia (CNS resident macrophages) and the consequent impacts on neuronal survival, excitability, and synaptic transmission are widely unknown, however. Here, we focused on electrical neuronal network rhythms in the gamma frequency band (30-70 Hz). Gamma oscillations are fundamental to higher brain functions, such as perception, attention, and memory, and they are exquisitely sensitive to metabolic and oxidative stress.