Lactate attenuates synaptic transmission and affects brain rhythms featuring high energy expenditure

• Verfasst von: Hollnagel, Jan-Oliver [VerfasserIn]
• Verfasst von: Lewen, Andrea [VerfasserIn]
• Verfasst von: Rozov, Andrei [VerfasserIn]
• Verfasst von: Kann, Oliver [VerfasserIn]
• Titel: Lactate attenuates synaptic transmission and affects brain rhythms featuring high energy expenditure
• Verf.angabe: Jan-Oliver Hollnagel, Tiziana Cesetti, Justus Schneider, Alina Vazetdinova, Fliza Valiullina-Rakhmatullina, Andrea Lewen, Andrei Rozov, and Oliver Kann
• E-Jahr: 2020
• Jahr: July 24, 2020
• Umfang: 30 S.
• Fussnoten: Available online 27 June 2020 ; Gesehen am 21.09.2020
• Titel Quelle: Enthalten in: iScience
• Ort Quelle: Amsterdam : Elsevier, 2018
• Jahr Quelle: 2020
• Band/Heft Quelle: 23(2020,7) Artikel-Nummer 101316, 30 Seiten
• ISSN Quelle: 2589-0042
• DOI: doi:10.1016/j.isci.2020.101316
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biochemistry
• Sach-SW: Cell Biology
• Sach-SW: Neuroscience
• K10plus-PPN: 1733466371

Abstract

Lactate shuttled from blood, astrocytes, and/or oligodendrocytes may serve as the major glucose alternative in brain energy metabolism. However, its effectiveness in fueling neuronal information processing underlying complex cortex functions like perception and memory is unclear. We show that sole lactate disturbs electrical gamma and theta-gamma oscillations in hippocampal networks by either attenuation or neural bursts. Bursting is suppressed by elevating the glucose fraction in substrate supply. By contrast, lactate does not affect electrical sharp wave-ripple activity featuring lower energy use. Lactate increases the oxygen consumption during the network states, reflecting enhanced oxidative ATP synthesis in mitochondria. Finally, lactate attenuates synaptic transmission in excitatory pyramidal cells and fast-spiking, inhibitory interneurons by reduced neurotransmitter release from presynaptic terminals, whereas action potential generation in the axon is regular. In conclusion, sole lactate is less effective and potentially harmful during gamma-band rhythms by omitting obligatory ATP delivery through fast glycolysis at the synapse.