UPF1-mediated RNA decay-danse macabre in a cloud

• Verfasst von: Lavysh, Daria [VerfasserIn]
• Verfasst von: Neu-Yilik, Gabriele [VerfasserIn]
• Titel: UPF1-mediated RNA decay-danse macabre in a cloud
• Verf.angabe: Daria Lavysh and Gabriele Neu-Yilik
• E-Jahr: 2020
• Jahr: 4 July 2020
• Umfang: 32 S.
• Fussnoten: Gesehen am 22.09.2020
• Titel Quelle: Enthalten in: Biomolecules
• Ort Quelle: Basel : MDPI, 2011
• Jahr Quelle: 2020
• Band/Heft Quelle: 10(2020,7) Artikel-Nummer 999, 32 Seiten
• ISSN Quelle: 2218-273X
• DOI: doi:10.3390/biom10070999
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: nonsense-mediated RNA decay
• Sach-SW: RNA turnover and surveillance
• Sach-SW: RNA-binding protein
• Sach-SW: UPF1
• Sach-SW: UPF1-mediated RNA decay
• K10plus-PPN: 1733551603

Abstract

Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA decay pathways that unfold around a common central effector protein called UPF1. While NMD in yeast appears to be a linear pathway, NMD in higher eukaryotes is a multifaceted phenomenon with high variability with respect to substrate RNAs, degradation efficiency, effector proteins and decay-triggering RNA features. Despite increasing knowledge of the mechanistic details, it seems ever more difficult to define NMD and to clearly distinguish it from a growing list of other UPF1-mediated RNA decay pathways (UMDs). With a focus on mammalian, we here critically examine the prevailing NMD models and the gaps and inconsistencies in these models. By exploring the minimal requirements for NMD and other UMDs, we try to elucidate whether they are separate and definable pathways, or rather variations of the same phenomenon. Finally, we suggest that the operating principle of the UPF1-mediated decay family could be considered similar to that of a computing cloud providing a flexible infrastructure with rapid elasticity and dynamic access according to specific user needs.