Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Chen, Mei [VerfasserIn]   i
 Glenn, Josephine V. [VerfasserIn]   i
 Dasari, Shilpa [VerfasserIn]   i
 Mcvicar, Carmel [VerfasserIn]   i
 Ward, Michael [VerfasserIn]   i
 Colhoun, Liza [VerfasserIn]   i
 Quinn, Michael [VerfasserIn]   i
 Bierhaus, Angelika [VerfasserIn]   i
 Xu, Heping [VerfasserIn]   i
 Stitt, Alan W. [VerfasserIn]   i
Titel:RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization
Verf.angabe:Mei Chen, Josephine V. Glenn, Shilpa Dasari, Carmel McVicar, Michael Ward, Liza Colhoun, Michael Quinn, Angelika Bierhaus, Heping Xu, Alan W. Stitt
E-Jahr:2014
Jahr:February 26, 2014
Umfang:11 S.
Teil:volume:9
 year:2014
 extent:11
Fussnoten:Gesehen am 23.09.2020
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2014
Band/Heft Quelle:9(2014) Artikel-Nummer e89548, 11 Seiten
ISSN Quelle:1932-6203
Abstract:Purpose RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macular degeneration (nvAMD). Methods RAGE null (RAGE−/−) mice and age-matched wild type (WT) control mice underwent laser photocoagulation to generate choroidal neovascularization (CNV) lesions which were then analyzed for morphology, S100B immunoreactivity and inflammatory cell infiltration. The chemotactic ability of bone marrow derived macrophages (BMDMs) towards S100B was investigated. Results RAGE expression was significantly increased in the retina during CNV of WT mice (p<0.001). RAGE−/− mice exhibited significantly reduced CNV lesion size when compared to WT controls (p<0.05). S100B mRNA was upregulated in the lasered WT retina but not RAGE−/− retina and S100B immunoreactivity was present within CNV lesions although levels were less when RAGE−/− mice were compared to WT controls. Activated microglia in lesions were considerably less abundant in RAGE−/− mice when compared to WT counterparts (p<0.001). A dose dependent chemotactic migration was observed in BMDMs from WT mice (p<0.05-0.01) but this was not apparent in cells isolated from RAGE−/− mice. Conclusions RAGE-S100B interactions appear to play an important role in CNV lesion formation by regulating pro-inflammatory and angiogenic responses. This study highlights the role of RAGE in inflammation-mediated outer retinal pathology.
DOI:doi:10.1371/journal.pone.0089548
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0089548
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089548
 DOI: https://doi.org/10.1371/journal.pone.0089548
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cytokines
 Eyes
 Immune cells
 Inflammation
 Macrophages
 Microglial cells
 Retina
 Retinal degeneration
K10plus-PPN:1733591532
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68639654   QR-Code
zum Seitenanfang