Status: Bibliographieeintrag
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| Verfasst von: | Lopez, Crisanto M. [VerfasserIn]  |
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| | Wallich, Reinhard [VerfasserIn] |
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| | Riesbeck, Kristian [VerfasserIn] |
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| | Skerka, Christine [VerfasserIn] |
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| | Zipfel, Peter F. [VerfasserIn] |
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| Titel: | Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin |
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| Verf.angabe: | Crisanto M. Lopez, Reinhard Wallich, Kristian Riesbeck, Christine Skerka, Peter F. Zipfel |
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| E-Jahr: | 2014 |
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| Jahr: | March 13, 2014 |
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| Fussnoten: | Gesehen am 23.09.2020 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 9(2014,3) Artikel-Nummer e90796, 10 Seiten |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | Candida albicans is a major cause of invasive fungal infections worldwide. Upon infection and when in contact with human plasma as well as body fluids the fungus is challenged by the activated complement system a central part of the human innate immune response. C. albicans controls and evades host complement attack by binding several human complement regulators like Factor H, Factor H-like protein 1 and C4BP to the surface. Gpm1 (Phosphoglycerate mutase 1) is one fungal Factor H/FHL1 -binding protein. As Gpm1 is surface exposed, we asked whether Gpm1 also contributes to host cell attachment. Here, we show by flow cytometry and by laser scanning microscopy that candida Gpm1 binds to human umbilical vein endothelial cells (HUVEC) to keratinocytes (HaCaT), and also to monocytic U937 cells. |
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| DOI: | doi:10.1371/journal.pone.0090796 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0090796 |
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| | Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090796 |
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| | DOI: https://doi.org/10.1371/journal.pone.0090796 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Candida albicans |
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| | Complement system |
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| | Endothelial cells |
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| | Extracellular matrix proteins |
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| | Flow cytometry |
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| | Fungal pathogens |
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| | Immune serum |
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| | Keratinocytes |
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| K10plus-PPN: | 173363472X |
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| Verknüpfungen: | → Zeitschrift |
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Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin / Lopez, Crisanto M. [VerfasserIn]; March 13, 2014 (Online-Ressource)
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