Association of cardiovascular risk assessment with early colorectal neoplasia detection in asymptomatic population

• Verfasst von: Chen, Yanwei [VerfasserIn]
• Verfasst von: Chen, Xuechen [VerfasserIn]
• Verfasst von: Wang, Xi [VerfasserIn]
• Verfasst von: Liu, Zhunzhun [VerfasserIn]
• Verfasst von: Zhou, Haibo [VerfasserIn]
• Verfasst von: Xu, Shu [VerfasserIn]
• Titel: Association of cardiovascular risk assessment with early colorectal neoplasia detection in asymptomatic population
• Titelzusatz: a systematic review and meta-analysis
• Verf.angabe: Yanwei Chen, Xuechen Chen, Xi Wang, Zhunzhun Liu, Haibo Zhou, Shu Xu
• E-Jahr: 2020
• Jahr: 11 August 2020
• Umfang: 9 S.
• Fussnoten: Gesehen am 24.09.2020
• Titel Quelle: Enthalten in: Clinical epidemiology
• Ort Quelle: Albany, Auckland : Dove Medical Press, 2009
• Jahr Quelle: 2020
• Band/Heft Quelle: 12(2020), Seite 865-873
• ISSN Quelle: 1179-1349
• DOI: doi:10.2147/CLEP.S262939
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cardiovascular disease
• Sach-SW: colorectal neoplasia
• Sach-SW: risk assessment
• K10plus-PPN: 1733688986

Abstract

Previous studies have shown a strong coexistence of colorectal neoplasia (CRN) and cardiovascular diseases (CVD). This study was aimed to summarize the available evidence on association of CVD risk with early CRN detection in asymptomatic populations. PubMed, Web of Science, and Embase were systematically searched for eligible studies published until Dec 20, 2019. Studies exploring the associations of recommended CVD risk assessment methods (e.g., risk scores, carotid artery plaque, and coronary artery calcium score [CACS]) with risk of CRN were included. Meta-analyses were conducted to determine the overall association of CVD risk with the CRN. A total of 12 studies were finally included. The association of carotid artery plaque with the risk of colorectal adenoma (AD) was weakest (pooled odds ratio [OR)] 1.27, 95% confidence interval [CI), 1.12, 1.45]. Participants with CACS>100 had about 2-fold increased risk of AD than those with CACS=0. The pooled ORs were 3.36 (95% CI, 2.15, 5.27) and 2.30 (95% CI, 1.69, 3.13) for the risk of advanced colorectal neoplasia (AN) and AD, respectively, in participants with Framingham risk score (FRS)>20%, when compared to participants at low risk (FRS<10%). FRS might help identify subgroups at increased risk for AN, but further studies are needed.