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Verfasst von:Palm, Frederick [VerfasserIn]   i
 Becher, Heiko [VerfasserIn]   i
 Grau, Armin J. [VerfasserIn]   i
Titel:Biomarkers of periodontitis and inflammation in ischemic stroke
Titelzusatz:A case-control study
Verf.angabe:Frederick Palm, Laura Lahdentausta, Timo Sorsa, Taina Tervahartiala, Pia Gokel, Florian Buggle, Anton Safer, Heiko Becher, Armin J. Grau and Pirkko Pussinen
Jahr:2014
Umfang:8 S.
Fussnoten:Article first published online: September 17, 2013 ; Gesehen am 24.09.2020
Titel Quelle:Enthalten in: Innate immunity
Ort Quelle:Thousand Oaks, Calif. : Sage, 2008
Jahr Quelle:2014
Band/Heft Quelle:20(2014), 5, Seite 511-518
ISSN Quelle:1753-4267
Abstract:Periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. In a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. The population comprised 98 patients with acute ischemic stroke (mean ± SD, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). Patients were more often edentulous and had fewer teeth than controls (13.8 ± 10.8 versus 16.6 ± 10.1). After adjusting for stroke risk factors and number of teeth, controls had higher saliva matrix metalloproteinase-8 (MMP-8), myeloperoxidase (MPO), IL-1β, Aggregatibacter actinomycetemcomitans, and serum LPS activity levels. Patients had higher serum MMP-8 and MPO, and they were more often qPCR-positive for A. actinomycetemcomitans (37.9% versus 19.0%) and for ≥3 periodontopathic species combined (50.0% versus 33.0%). We conclude that controls more often had evidence of current periodontal infection with higher periodontal pathogen amount, endotoxemia, local inflammation and tissue destruction. Stroke patients more often had evidence of end-stage periodontitis with edentulism and missing teeth. They were more often carriers of several periodontopathic pathogens in saliva, especially A. actinomycetemcomitans. Additionally, inflammatory burden may contribute to high systemic inflammation associated with elevated stroke susceptibility.
DOI:doi:10.1177/1753425913501214
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1177/1753425913501214
 Volltext: https://journals.sagepub.com/doi/10.1177/1753425913501214
 DOI: https://doi.org/10.1177/1753425913501214
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1733692177
Verknüpfungen:→ Zeitschrift

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